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1. (WO2001001149) TROPONIN I COMPOSITION

Pub. No.:    WO/2001/001149    International Application No.:    PCT/IB2000/000875
Publication Date: Fri Jan 05 00:59:59 CET 2001 International Filing Date: Thu Jun 29 01:59:59 CEST 2000
IPC: G01N 33/68
G01N 33/96
Applicants: SPECTRAL DIAGNOSTICS, INC.
LIU, Shigui
ZHANG, Min, Yuan
SHI, Qinwei
Inventors: LIU, Shigui
ZHANG, Min, Yuan
SHI, Qinwei
Title: TROPONIN I COMPOSITION
Abstract:
The present invention relates to stable compositions useful as primary standards and calibrators and controls comprising a cardiac troponin I (cTnI) such as native, recombinant, addition and deletion forms thereof, whether or not complexed with other troponin subunits such as TnC and/or TnT, in an inactivated human serum. The compositions are obtained by incubating troponin complexes with human serum. The compositions are characterized by an immunodetectability ratio of epitopes on the N-terminal segment to epitopes on the C-terminal segment substantially equivalent to that of pooled, fresh serum from acute myocardial infarction patients.