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Pub. No.:    WO/2001/001149    International Application No.:    PCT/IB2000/000875
Publication Date: 04.01.2001 International Filing Date: 28.06.2000
Chapter 2 Demand Filed:    26.01.2001    
G01N 33/68 (2006.01), G01N 33/96 (2006.01)
Applicants: SPECTRAL DIAGNOSTICS, INC. [CA/CA]; 135-2 The West Mall, Toronto, Ontario M9C 1C2 (CA) (For All Designated States Except US).
LIU, Shigui [US/US]; (CA) (For US Only).
ZHANG, Min, Yuan [CA/CA]; (CA) (For US Only).
SHI, Qinwei [CA/CA]; (CA) (For US Only)
Inventors: LIU, Shigui; (CA).
ZHANG, Min, Yuan; (CA).
SHI, Qinwei; (CA)
Priority Data:
09/342,578 29.06.1999 US
Abstract: front page image
(EN)The present invention relates to stable compositions useful as primary standards and calibrators and controls comprising a cardiac troponin I (cTnI) such as native, recombinant, addition and deletion forms thereof, whether or not complexed with other troponin subunits such as TnC and/or TnT, in an inactivated human serum. The compositions are obtained by incubating troponin complexes with human serum. The compositions are characterized by an immunodetectability ratio of epitopes on the N-terminal segment to epitopes on the C-terminal segment substantially equivalent to that of pooled, fresh serum from acute myocardial infarction patients.
(FR)La présente invention concerne des compositions stables convenant en tant qu'étalons et d'étalons de référence et témoin principaux comprenant une troponine I cardiaque (cTnI), telle que ses formes native, de recombinaison, d'addition et de délétion, complexées ou non au moyen d'autres sous-unités de troponine, telles que TnC et/ou TnT, dans un sérum humain inactif. On obtient ces compositions par incubation de complexes de troponine avec du sérum humain. Ces compositions se caractérisent par un rapport d'immunodétectabilité entre les épitopes du segment N-terminal et ceux du segment C-terminal, sensiblement équivalent à celui d'un mélange de sérums frais provenant de patients souffrant de l'infarctus aigu du myocarde.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)