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1. (WO2001000828) COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER

Pub. No.:    WO/2001/000828    International Application No.:    PCT/US2000/018061
Publication Date: Fri Jan 05 00:59:59 CET 2001 International Filing Date: Sat Jul 01 01:59:59 CEST 2000
IPC: A61K 38/00
C07K 14/47
C12Q 1/68
Applicants: CORIXA CORPORATION
WANG, Tongtong
BANGUR, Chaitanya, S.
LODES, Michael, J.
FANGER, Gary, R.
VEDVICK, Thomas, S.
CARTER, Darrick
RETTER, Marc, W.
MANNION, Jane
Inventors: WANG, Tongtong
BANGUR, Chaitanya, S.
LODES, Michael, J.
FANGER, Gary, R.
VEDVICK, Thomas, S.
CARTER, Darrick
RETTER, Marc, W.
MANNION, Jane
Title: COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER
Abstract:
Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.