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1. (WO2001000788) COMPOSITIONS, KITS, AND METHODS FOR MODULATING SURVIVAL AND DIFFERENTIATION OF MULTI-POTENTIAL HEMATOPOIETIC PROGENITOR CELLS

Pub. No.:    WO/2001/000788    International Application No.:    PCT/US2000/017345
Publication Date: Fri Jan 05 00:59:59 CET 2001 International Filing Date: Sat Jun 24 01:59:59 CEST 2000
IPC: C12N 5/078
C12N 5/0789
A61K 35/12
Applicants: NORTHWESTERN UNIVERSITY
Inventors: LEFEBVRE, Phil
LIN, Jiandie
COHEN, Isaac
LINZER, Daniel
Title: COMPOSITIONS, KITS, AND METHODS FOR MODULATING SURVIVAL AND DIFFERENTIATION OF MULTI-POTENTIAL HEMATOPOIETIC PROGENITOR CELLS
Abstract:
The invention includes compositions, kits, and methods for modulating survival and differentiation of mammalian multi-potential hematopoietic progenitor cells using a placental glycoprotein hormone of the murine prolactin family, namely either murine prolactin-like protein E or murine prolactin-like protein F. The compositions, kits, and methods described herein can be used, for example, for in vitro or ex vivo expansion of hematopoietic precursor cells or to treat a disorder associated with aberrant hematopoiesis (e.g., pre-eclampsia and thrombocytopenia).