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Machine translation
1. (WO2001000788) COMPOSITIONS, KITS, AND METHODS FOR MODULATING SURVIVAL AND DIFFERENTIATION OF MULTI-POTENTIAL HEMATOPOIETIC PROGENITOR CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/000788    International Application No.:    PCT/US2000/017345
Publication Date: 04.01.2001 International Filing Date: 23.06.2000
IPC:
C12N 5/078 (2010.01), C12N 5/0789 (2010.01), A61K 35/12 (2006.01)
Applicants: NORTHWESTERN UNIVERSITY [US/US]; 1801 Maple Avenue, Evanston, IL 60201-3135 (US)
Inventors: LEFEBVRE, Phil; (US).
LIN, Jiandie; (US).
COHEN, Isaac; (US).
LINZER, Daniel; (US)
Agent: COLBY, Gary, D.; Akin, Gump, Strauss, Hauer & Feld, L.L.P., One Commerce Square, 22nd floor, 2005 Market Street, Philadelphia, PA 19103-7086 (US)
Priority Data:
60/141,060 25.06.1999 US
60/162,472 29.10.1999 US
Title (EN) COMPOSITIONS, KITS, AND METHODS FOR MODULATING SURVIVAL AND DIFFERENTIATION OF MULTI-POTENTIAL HEMATOPOIETIC PROGENITOR CELLS
(FR) COMPOSITIONS, KITS ET METHODES DE MODULATION DE SURVIE ET DE DIFFERENTIATION DE CELLULES PRECURSEURS HEMATOPOIETIQUES MULTI-POTENTIEL
Abstract: front page image
(EN)The invention includes compositions, kits, and methods for modulating survival and differentiation of mammalian multi-potential hematopoietic progenitor cells using a placental glycoprotein hormone of the murine prolactin family, namely either murine prolactin-like protein E or murine prolactin-like protein F. The compositions, kits, and methods described herein can be used, for example, for in vitro or ex vivo expansion of hematopoietic precursor cells or to treat a disorder associated with aberrant hematopoiesis (e.g., pre-eclampsia and thrombocytopenia).
(FR)L'invention concerne des compositions, des kits et des méthodes de modulation de survie et de différentiation de cellules précurseurs hématopoïétiques multi-potentiel mammaliennes, à l'aide d'une hormone de glycoprotéine placentaire de la famille prolactine murine, à savoir la protéine E de type prolactine murine ou la protéine F de type prolactine murine. Ces compositions, ces kits et ces méthodes peuvent s'utiliser, par exemple, pour l'expansion in vitro ou ex vivo des cellules précurseurs hématopoïétiques ou pour traiter un trouble associé à l'hématopoïèse aberrante (par exemple, la pré-éclampsie et la thrombocytopénie).
Designated States: AU, CA, JP.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)