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1. (WO2001000673) MEMBRANE-ASSOCIATED AND SECRETED PROTEINS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/000673    International Application No.:    PCT/US2000/018198
Publication Date: 04.01.2001 International Filing Date: 29.06.2000
Chapter 2 Demand Filed:    23.01.2001    
IPC:
C07K 14/47 (2006.01)
Applicants: MILLENNIUM PHARMACEUTICALS, INC. [US/US]; 75 Sidney Street, Cambridge, MA 02139 (US)
Inventors: BARNES, Thomas, M.; (US).
FRASER, Christopher, C.; (US).
WRIGHTON, Nicholas; (US).
MYERS, Paul; (US).
BUSFIELD, Samantha, J.; (US).
SHARP, John, D.; (US)
Agent: CORUZZI, Laura, A.; Pennie & Edmonds LLP, 1155 Avenue of the Americas, New York, NY 10036 (US)
Priority Data:
09/345,464 30.06.1999 US
Title (EN) MEMBRANE-ASSOCIATED AND SECRETED PROTEINS AND USES THEREOF
(FR) PROTEINES ASSOCIEES AUX MEMBRANES ET SECRETEES, ET LEURS UTILISATIONS
Abstract: front page image
(EN)The invention provides isolated nucleic acid molecules, designated INTERCEPT 340, MANGO 003, MANGO 347, TANGO 272, TANGO 295, TANGO 354, and TANGO 378 which encode wholly secreted or membrane-associated proteins. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
(FR)Cette invention concerne des molécules d'acide nucléique isolées, dites INTERCEPT 340, MANGO 003, MANGO 347, TANGO 272, TANGO 295, TANGO 354, et TANGO 378, qui codent pour des protéines entièrement sécrétées ou associées aux membranes. L'invention porte également sur des molécules d'acide nucléique antisens, des vecteurs d'expression renfermant les molécules d'acide nucléique selon l'invention, des cellules hôtes dans lesquels les vecteurs d'expression ont été introduits, et des animaux transgéniques non humains dans lesquels la molécule d'acides nucléiques selon l'invention a été introduite ou interrompue. De plus, l'invention concerne des polypeptides isolés des peptides antigéniques et des anticorps. Elle concerne enfin des techniques de diagnostic et de criblage ainsi que des méthodes thérapeutiques faisant intervenir les compostions selon l'invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)