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Machine translation
1. (WO2001000659) BENZIMIDAZOLONE PEPTIDOMIMETICS AS THROMBIN RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/000659    International Application No.:    PCT/US2000/017751
Publication Date: 04.01.2001 International Filing Date: 28.06.2000
Chapter 2 Demand Filed:    23.01.2001    
IPC:
A61K 38/00 (2006.01), C07D 235/26 (2006.01), C07K 5/06 (2006.01), G01R 1/067 (2006.01), G01R 1/073 (2006.01), G01R 3/00 (2006.01), H05K 3/40 (2006.01)
Applicants: ORTHO-MCNEIL PHARMACEUTICAL, INC. [US/US]; U.S. Route #202, P.O. Box 300, Raritan, NJ 08869-0602 (US).
COR THERAPEUTICS, INC. [US/US]; 256 East Grand Avenue, South San Francisco, CA 94080 (US)
Inventors: ZHANG, Han-Cheng; (US).
MARYANOFF, Bruce, E.; (US).
MCCOMSEY, David, F.; (US).
WHITE, Kimberly, B.; (US)
Agent: WOODROW, Hal, Brent; Johnson & Johnson, One Johnson & Johnson Plaza, New Brunswick, NJ 08903 (US)
Priority Data:
60/141,552 29.06.1999 US
09/599,826 22.06.2000 US
Title (EN) BENZIMIDAZOLONE PEPTIDOMIMETICS AS THROMBIN RECEPTOR ANTAGONISTS
(FR) PEPTIDOMIMETIQUES A BENZIMIDAZOLONE COMME ANTAGONISTES DE RECEPTEUR DE THROMBINE
Abstract: front page image
(EN)The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
(FR)La présente invention concerne des composés peptidomimétiques à benzimidazolone utiles comme antagonistes de récepteur de thrombine destinés au traitement de maladies associées avec une thrombose, une resténose, de l'hypertension, une insuffisance cardiaque, de l'arythmie, une inflammation, une angine, une attaque, de l'athérosclérose, des conditions ischémiques, des troubles reliés à l'angiogénèse, un cancer et des troubles neurodégénérescents. Elle concerne aussi des compositions pharmaceutiques comprenant les peptidomimétiques à benzimidazolone substitués de l'invention et des méthodes de traitement de troubles liés au récepteur de thrombine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)