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1. (WO2001000621) NOVEL QUATERNARY AMMONIUM DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL USE

Pub. No.:    WO/2001/000621    International Application No.:    PCT/FR2000/001731
Publication Date: Fri Jan 05 00:59:59 CET 2001 International Filing Date: Fri Jun 23 01:59:59 CEST 2000
IPC: C07C 237/20
C07D 259/00
C07D 279/02
C07D 409/06
C07D 417/12
C07F 13/00
C07H 5/06
Applicants: LES LABORATOIRES SERVIER
INSTITUT NATIONAL DE LA SANTE ET DE LA REHCERCHE MEDICALE
MADELMONT, Jean-Claude
GIRAUD, Isabelle
NICOLAS, Colette
MAURIZIS, Jean-Claude
RAPP, Maryse
OLLIER, Monique
RENARD, Pierre
CAIGNARD, Daniel-Henri
Inventors: MADELMONT, Jean-Claude
GIRAUD, Isabelle
NICOLAS, Colette
MAURIZIS, Jean-Claude
RAPP, Maryse
OLLIER, Monique
RENARD, Pierre
CAIGNARD, Daniel-Henri
Title: NOVEL QUATERNARY AMMONIUM DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL USE
Abstract:
The invention concerns compounds of formulae (Ia) or (Ib) wherein M: represents a molecule for use in the treatment or diagnosis of pathologies affecting the cartilage; R1, R2, R3 represent an alkyl group, or R1, R 2, R3 together with the nitrogen atom which bears them form a heterocycle; X represents a C1-C6 alkyl chain wherein one or several -CH2- groups are optionally substituted by a sulphur, an oxygen atom, a -NR, -CO-, -CO-NH-, -CO2-, SO- or SO2- group; n represents 0 or 1; Hal represents a halogen atom, or the formula (Ib); R4 represents an alkyl group; Hal represents a halogen atom. General formula (F1) represents a molecule for use in the treatment or diagnosis of pathologies affecting the cartilage, provided that the nitrogen atom can optionally be included in a saturated or unsaturated nitrogenous heterocyclic system, or involved in a double bond.