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1. (WO2001000613) BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/000613    International Application No.:    PCT/JP2000/004204
Publication Date: 04.01.2001 International Filing Date: 27.06.2000
Chapter 2 Demand Filed:    27.06.2000    
IPC:
C07D 403/12 (2006.01)
Applicants: FUJI PHOTO FILM CO., LTD. [JP/JP]; 210 Nakanuma, Minami-ashigara-shi, Kanagawa 250-0193 (JP) (For All Designated States Except US).
AOKI, Kozo [JP/JP]; (JP) (For US Only).
AIKAWA, Kazuhiro [JP/JP]; (JP) (For US Only).
KAWAKAMI, Masayuki [JP/JP]; (JP) (For US Only)
Inventors: AOKI, Kozo; (JP).
AIKAWA, Kazuhiro; (JP).
KAWAKAMI, Masayuki; (JP)
Agent: IMAMURA, Masazumi; 5th Floor, KRF Bldg., 5-5, Kyobashi 1-chome, Chuo-ku, Tokyo 104-0031 (JP)
Priority Data:
11/185568 30.06.1999 JP
Title (EN) BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME
(FR) COMPOSES DE BENZIMIDAZOLE ET MEDICAMENTS LES CONTENANT
Abstract: front page image
(EN)Benzimidazole compounds represented by general formula (I) or salts thereof, which exhibit an inhibitory activity against the conversion of macrophages into foam cells and are useful as the active ingredient of drugs to be used in the prevention and/or treatment of arteriosclerosis wherein R1 is a substituent on the benzene ring which is selected from the group consisting of hydrogen, halogeno, lower alky, and lower alkoxy; R2 is hydrogen, alkyl, or acyl; and R3 is a substituent on the ring containing nitrogen and Z; Z is a divalent group constituting a five- or six-membered ring; L is C4-C8 alkylene or an ethylene-oxy group represented by the general formula: (CH2CH2O)nCH2CH2 (wherein n is 1 or 2); and X is O or S.
(FR)L'invention concerne des composés correspondant à la formule générale (I) ou leurs sels, présentant une activité inhibitrice de la conversion de macrophages en cellules spumeuses et utile comme principe actif de médicaments utilisés pour prévenir et traiter l'artériosclérose: (I). Dans la formule de la présente invention R1 représente un substituant sur l'anneau benzénique choisi parmi le groupe comprenant hydrogène, halogène, alkyle inférieur et alcoxy inférieur; R2 représente hydrogène, alkyle, ou acyle; et R3 représente un substituant sur l'anneau contenant de l'azote et Z; Z représente un groupe bivalent constitué de 5 ou 6 chaînons; L représente un alkylène en C4-C8 ou un groupe oxy-éthylène représenté par la formule générale: (CH2CH2O) nCH2CH2 (dans laquelle n représente 1 ou 2); et X représente O ou S.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)