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1. (WO2001000613) BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME

Pub. No.:    WO/2001/000613    International Application No.:    PCT/JP2000/004204
Publication Date: Fri Jan 05 00:59:59 CET 2001 International Filing Date: Wed Jun 28 01:59:59 CEST 2000
IPC: C07D 403/12
Applicants: FUJI PHOTO FILM CO., LTD.

AOKI, Kozo

AIKAWA, Kazuhiro

KAWAKAMI, Masayuki

Inventors: AOKI, Kozo

AIKAWA, Kazuhiro

KAWAKAMI, Masayuki

Title: BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME
Abstract:
Benzimidazole compounds represented by general formula (I) or salts thereof, which exhibit an inhibitory activity against the conversion of macrophages into foam cells and are useful as the active ingredient of drugs to be used in the prevention and/or treatment of arteriosclerosis wherein R1 is a substituent on the benzene ring which is selected from the group consisting of hydrogen, halogeno, lower alky, and lower alkoxy; R2 is hydrogen, alkyl, or acyl; and R3 is a substituent on the ring containing nitrogen and Z; Z is a divalent group constituting a five- or six-membered ring; L is C¿4?-C8 alkylene or an ethylene-oxy group represented by the general formula: (CH2CH2O)nCH2CH2 (wherein n is 1 or 2); and X is O or S.