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1. (WO2001000581) LIGANDS BASED ON CHIRAL 2-AMINO-2'-HYDROXY-1,1'-BINAPHTHYL AND RELATED FRAMEWORKS FOR ASYMMETRIC CATALYSIS

Pub. No.:    WO/2001/000581    International Application No.:    PCT/US2000/017903
Publication Date: Fri Jan 05 00:59:59 CET 2001 International Filing Date: Fri Jun 30 01:59:59 CEST 2000
IPC: C07C 45/50
C07C 45/69
C07C 45/72
C07C 215/86
C07C 251/24
C07C 275/32
C07C 311/09
C07C 311/21
C07C 381/06
C07D 213/38
C07D 213/53
C07D 213/81
C07D 235/06
C07D 237/08
C07D 237/24
C07D 307/52
C07D 333/22
C07D 521/00
C07F 9/50
C07F 9/58
C07F 9/6571
C07F 9/6584
Applicants: THE PENN STATE RESEARCH FOUNDATION
Inventors: ZHANG, Xumu
Title: LIGANDS BASED ON CHIRAL 2-AMINO-2'-HYDROXY-1,1'-BINAPHTHYL AND RELATED FRAMEWORKS FOR ASYMMETRIC CATALYSIS
Abstract:
The present invention includes array of new chiral ligands that are optically active or racemic. These ligands are bidentate, tridentate, tetradentate or pentadentate ligands which include P-P, P-N, N-N, mixed P-N, Schiff base or carbene sites. The present invention further includes a catalyst prepared by a process, which includes contacting a transition metal salt, or a complex thereof, and a ligand according to the present invention. The present invention still further includes a process for preparation of an asymmetric compound. In this process, a substrate capable of forming an asymmetric product by an asymmetric reaction and a catalyst according to the present invention are contacted to produce an asymmetric product. Transition metal complexes with these ligands are effective catalysts for asymmetric reactions. Applicant has discovered that asymmetric products can be prepared using the chiral catalysts according to the present invention in enantioselective reactions, such as hydrogenation, hydroformylation, Michael addition, Heck reaction, Aldol reaction, allylic alkylation, cyclopropanation, epoxidation, and olefin metathesis.