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Machine translation
1. (WO2001000576) INDOLE AND INDAZOLE UREA-PEPTOIDS AS THROMBIN RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/000576 International Application No.: PCT/US2000/018021
Publication Date: 04.01.2001 International Filing Date: 29.06.2000
Chapter 2 Demand Filed: 22.01.2001
IPC:
C07D 209/14 (2006.01) ,C07D 231/56 (2006.01)
Applicants: ORTHO-MCNEIL PHARMACEUTICAL, INC.[US/US]; U.S. Route #202 P.O. Box 300 Raritan, NJ 08869-0602, US
COR THERAPEUTICS, INC.[US/US]; 256 East Grand Avenue South San Francisco, CA 94080, US
Inventors: MCCOMSEY, David, F.; US
HOEKSTRA, William, J.; US
MARYANOFF, Bruce, E.; US
ZHANG, Han-Cheng; US
Agent: CIAMPORCERO, Audley, A., Jr.; Johnson & Johnson One Johnson & Johnson Plaza New Brunswick, NJ 08933 , US
JOHNSON, Philip, S. ; Johnson & Johnson One Johnson & Johnson Plaza New Brunswick, NJ 08933, US
Priority Data:
09/603,22926.06.2000US
60/141,55529.06.1999US
Title (EN) INDOLE AND INDAZOLE UREA-PEPTOIDS AS THROMBIN RECEPTOR ANTAGONISTS
(FR) UREE-PEPTOIDES DE TYPE INDOLE ET INDAZOLE UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR DE THROMBINE
Abstract:
(EN) The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole and indazole urea-peptoid compounds of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
(FR) L'invention se rapporte à de nouveaux composés urée-peptoïdes de type indole et indazole qui s'avèrent utiles en tant qu'antagonistes du récepteur de thrombine pour le traitement de maladies associées à des troubles du type thrombose, resténose, hypertension, insuffisance cardiaque, arythmie, inflammation, angine de poitrine, apoplexie, athérosclérose, troubles ischémiques, troubles liés à l'angiogenèse, cancer et troubles neurodégénératifs. L'invention se rapporte également à des compositions pharmaceutiques comportant les composés substitués urée-peptoïdes de type indole et indazole ainsi qu'à des méthodes de traitement de troubles dont la médiation est assurée par le récepteur de thrombine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)