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1. (WO2001000570) INTERMEDIATES FOR THE SYNTHESIS OF BENZIMIDAZOLE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/000570    International Application No.:    PCT/JP2000/004213
Publication Date: 04.01.2001 International Filing Date: 27.06.2000
Chapter 2 Demand Filed:    27.06.2000    
IPC:
C07C 271/28 (2006.01), C07D 417/12 (2006.01)
Applicants: SANKYO COMPANY, LIMITED [JP/JP]; 5-1, Nihonbashi Honcho 3-chome, Chuo-ku, Tokyo 103-8426 (JP) (For All Designated States Except US).
KISHI, Naoyuki [JP/JP]; (JP) (For US Only).
NAKAMURA, Yoshitaka [JP/JP]; (JP) (For US Only).
ABE, Narumi [JP/JP]; (JP) (For US Only).
TAKEBAYASHI, Toyonori [JP/JP]; (JP) (For US Only)
Inventors: KISHI, Naoyuki; (JP).
NAKAMURA, Yoshitaka; (JP).
ABE, Narumi; (JP).
TAKEBAYASHI, Toyonori; (JP)
Agent: OHNO, Akio; Sankyo Company, Limited, 2-58, Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710 (JP)
Priority Data:
11/181898 28.06.1999 JP
Title (EN) INTERMEDIATES FOR THE SYNTHESIS OF BENZIMIDAZOLE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF
(FR) INTERMEDIAIRES POUR LA SYNTHESE DE COMPOSES DE BENZIMIDAZOLE ET PROCEDE DE PREPARATION
Abstract: front page image
(EN)Problem: To provide intermediates for the synthesis of benzimidazole compounds having an excellent antihyperglycemic activity or salts thereof and a process for the preparation thereof. Means for solutions: A process for the preparation of benzimidazole compounds (I), characterized by condensing an amine derivative (III) with a carboxylic acid derivative (II) to form a compound (IV) and subjecting the compound (IV) to ring closure in the presence of an acid (wherein R1 is C1-C6alkyl, C1-C6alkoxy, or the like; R2 is C1-C6alkyl; and R3 is hydrogen or a protective group).
(FR)L'invention concerne des intermédiaires pour la synthèse de composés de benzimidazole présentant une excellente activité antihyperglycémique ou leurs sels et un procédé de préparation de ceux-ci. Le procédé de préparation de composés de benzimidazole (I) est caractérisé par la condensation d'un dérivé d'amine (III) avec un dérivé d'acide carboxylique (II) pour former un composé (IV) et soumettre ce composé (IV) à la fermeture du cycle en présence d'un acide (dans laquelle R1 représente alkyle C1-C6, alcoxy C1-C6 ou similaires; R2 représente alkyle C1-C6; et R3 représente hydrogène ou un groupe protecteur).
Designated States: AU, BR, CA, CN, CZ, HU, ID, IL, IN, KR, MX, NO, NZ, PL, RU, TR, US, ZA.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)