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1. (WO2001000233) VACCINE COMPOSITIONS USING ANTIGENS ENCAPSULATED WITHIN ALGINATE MICROSPHERES FOR ORAL ADMINISTRATION AND PREPARATION PROCESS THEREOF

Pub. No.:    WO/2001/000233    International Application No.:    PCT/KR1999/000466
Publication Date: Fri Jan 05 00:59:59 CET 2001 International Filing Date: Fri Aug 20 01:59:59 CEST 1999
IPC: A61K 9/00
A61K 9/16
A61K 47/36
Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
JEONG, Seo, Young
KWON, Ick, Chan
PARK, Joo, Ae
Inventors: JEONG, Seo, Young
KWON, Ick, Chan
PARK, Joo, Ae
Title: VACCINE COMPOSITIONS USING ANTIGENS ENCAPSULATED WITHIN ALGINATE MICROSPHERES FOR ORAL ADMINISTRATION AND PREPARATION PROCESS THEREOF
Abstract:
The present invention relates to vaccine compositions for oral administration consisting essentially of a protein antigen, in an amount effective to induce an immune response to said antigen, encapsulated in alginate microspheres, and to preparation process thereof. More particularly, the present invention relates to vaccine compositions for oral administration consisting of a protein antigen encapsulated in biodegradable alginate microspheres by the diffusion-controlled interfacial gelation technique which produces microspheres having less than 5 νm of diameter, and preparation process thereof.