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1. (WO2001000215) COMPOSITIONS FOR TREATING OR PREVENTING NEURODEGENERATION AND COGNITIVE DECLINE

Pub. No.:    WO/2001/000215    International Application No.:    PCT/US2000/017200
Publication Date: Fri Jan 05 00:59:59 CET 2001 International Filing Date: Sat Jun 24 01:59:59 CEST 2000
IPC: A61K 31/4748
A61K 45/06
Applicants: WAKE FOREST UNIVERSITY
NOTELOVITZ, Morris
Inventors: NOTELOVITZ, Morris
CLARKSON, Thomas
PAN, Yuanlong
ANTHONY, Mary
Title: COMPOSITIONS FOR TREATING OR PREVENTING NEURODEGENERATION AND COGNITIVE DECLINE
Abstract:
A composition for improving memory and concentration in mammals with disorders associated with memory impairment. The composition comprises a combination of at least one phytoestrogen and at least one acetylcholinesterase inhibitor such as Huperzine A, or any derivative, analog, metabolite or combination thereof. The composition may further include at least one mammalian estrogen. The method of the invention comprises the co-administration of at least one phytoestrogen and at least one acetylcholinesterase inhibitor in a therapeutically effective amount. Additionally, a mammalian estrogen may be co-administered.