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1. (WO2001000213) SRC KINASE INHIBITOR COMPOUNDS

Pub. No.:    WO/2001/000213    International Application No.:    PCT/US2000/017443
Publication Date: Fri Jan 05 00:59:59 CET 2001 International Filing Date: Tue Jun 27 01:59:59 CEST 2000
IPC: C07D 401/14
C07D 403/04
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/12
C07D 471/04
C07D 487/04
Applicants: MERCK & CO., INC.
ARMSTRONG, Helen, M.
BERESIS, Richard
GOULET, Joung, L.
HOLMES, Mark, A.
HONG, Xingfang
MILLS, Sander, G.
PARSONS, William, H.
SINCLAIR, Peter, J.
STEINER, Mark, G.
WONG, Frederick
ZALLER, Dennis, M.
Inventors: ARMSTRONG, Helen, M.
BERESIS, Richard
GOULET, Joung, L.
HOLMES, Mark, A.
HONG, Xingfang
MILLS, Sander, G.
PARSONS, William, H.
SINCLAIR, Peter, J.
STEINER, Mark, G.
WONG, Frederick
ZALLER, Dennis, M.
Title: SRC KINASE INHIBITOR COMPOUNDS
Abstract:
Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atherosclerosis, graft rejection, rheumatoid arthritis and psoriasis.