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1. (WO2001000195) PHARMACEUTICAL COMPOSITIONS COMPRISING NITRIC SYNTHASE INHIBITORS FOR TREATING DECREASE BLOOD PRESSURE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/000195 International Application No.: PCT/IL2000/000369
Publication Date: 04.01.2001 International Filing Date: 23.06.2000
Chapter 2 Demand Filed: 24.01.2001
IPC:
A61K 31/198 (2006.01)
Applicants: COTTER, Gad[IL/IL]; IL
Inventors: COTTER, Gad; IL
Agent: REINHOLD COHN AND PARTNERS; P.O. Box 4060 61040 Tel-Aviv, IL
Priority Data:
13063824.06.1999IL
Title (EN) PHARMACEUTICAL COMPOSITIONS COMPRISING NITRIC SYNTHASE INHIBITORS FOR TREATING DECREASE BLOOD PRESSURE
(FR) COMPOSITIONS PHARMACEUTIQUES CONTENANT DES INHIBITEURS D'OXYDE NITRIQUE SYNTHASE
Abstract:
(EN) A pharmaceutical composition comprising a nitric oxide synthase inhibitor and a pharmaceutically acceptable carrier for the treatment of decreased blood pressure to below 120 mmHg systolic, symptomatic hypotension, cardiogenic shock occurring during an acute coronary syndrome or cardiogenic shock occurring during or after coronary artery bypass surgery or during or after any other cardiac surgery. Preferred inhibitors are N$g(v)-substituted-L-arginine compounds such as L-NMMA and L-NAME. A method for treating patients suffering from the above conditions comprising administering an effective amount of a nitric oxide synthase inhibitor is also disclosed.
(FR) L'invention concerne une composition pharmaceutique contenant un inhibiteur d'oxyde nitrique synthase et un excipient pharmaceutiquement acceptable destinés à traiter les baisses de la tension artérielle systolique à un niveau inférieur à 120 mmHg, l'hypotension symptomatique, les chocs cardiogènes survenant lors de syndromes coronariens aigus ou les chocs cardiogènes survenant pendant ou après un pontage aortocoronarien ou pendant ou après toute autre chirurgie cardiaque. Des inhibiteurs préférés sont des composés N$g(v)-substitués-L-arginine, tels que L-NMMA et L-NAME. L'invention concerne également une méthode de traitement de patients affectés par les états pathologiques susmentionnés, ladite méthode consistant à administrer à ces patients une quantité efficace d'un inhibiteur d'oxyde nitrique synthase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)