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1. WO2000071520 - ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS

Publication Number WO/2000/071520
Publication Date 30.11.2000
International Application No. PCT/US2000/011256
International Filing Date 27.04.2000
Chapter 2 Demand Filed 08.12.2000
IPC
C07C 205/37 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
205Compounds containing nitro groups bound to a carbon skeleton
27the carbon skeleton being further substituted by etherified hydroxy groups
35having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
36to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
37the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
C07C 217/16 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
14the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
16the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
C07C 217/20 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
14the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
18the six-membered aromatic ring or condensed ring system containing that ring being further substituted
20by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
C07D 213/65 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
63One oxygen atom
65attached in position 3 or 5
C07D 213/70 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
70Sulfur atoms
C07D 317/64 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
317Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08having the hetero atoms in positions 1 and 3
44ortho- or peri-condensed with carbocyclic rings or ring systems
46condensed with one six-membered ring
48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
62with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
64Oxygen atoms
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • TARGACEPT, INC. [US]/[US] (AllExceptUS)
  • DULL, Gary, Maurice [US]/[US] (UsOnly)
  • REICH, Erin, E. [US]/[US] (UsOnly)
  • WAGNER, Jared, Miller [US]/[US] (UsOnly)
  • BHATTI, Balwinder, Singh [US]/[US] (UsOnly)
  • CONSILVIO, Michael, B. [US]/[US] (UsOnly)
Inventors
  • DULL, Gary, Maurice
  • REICH, Erin, E.
  • WAGNER, Jared, Miller
  • BHATTI, Balwinder, Singh
  • CONSILVIO, Michael, B.
Agents
  • SAJOVEC, F., Michael
Priority Data
09/317,32724.05.1999US
09/327,14907.06.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS
(FR) COMPOSITIONS PHARMACEUTIQUES ET METHODES D'UTILISATION
Abstract
(EN)
Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines and arylthioalkylamines, including pyridyloxylalkylamines, phenoxyalkylamines, pyridylthiolalkylamines and phenylthioalkylamines of the formula (I) where X is nitrogen or carbon. X' are individually nitrogen, N-O or carbon.
(FR)
Des patients susceptibles de souffrir ou souffrant de pathologies ou de troubles, tel que les troubles du système nerveux central, sont traités par l'administration d'aryloxyalkylamines et d'arylthioalkylamines, comprenant des pyridyloxylalkylamines, des phénoxyalkylamines, des pyridylthiolalkylamines et des phénylthiolalkylamines.
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