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1. WO2000068229 - (S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS

Publication Number WO/2000/068229
Publication Date 16.11.2000
International Application No. PCT/IN2000/000054
International Filing Date 08.05.2000
Chapter 2 Demand Filed 20.11.2000
IPC
A61K 31/4745 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4738ortho- or peri-condensed with heterocyclic ring systems
4745condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
C07D 455/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
455Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo quinolizines, e.g. berberine
03containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo quinolizines, e.g. berberine
04containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
CPC
A61K 31/4745
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4738ortho- or peri-condensed with heterocyclic ring systems
4745condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
06for tuberculosis
C07B 2200/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
07Optical isomers
C07C 279/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group , the singly-bound nitrogen atoms not being part of nitro or nitroso groups
04having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
14being further substituted by carboxyl groups
C07D 455/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
455Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
03containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
04containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
Applicants
  • WOCKHARDT LIMITED [IN]/[IN] (AllExceptUS)
  • PATEL, M., V. [IN]/[IN] (UsOnly)
  • GUPTE, S., V. [IN]/[IN] (UsOnly)
  • CHUGH, Y. [IN]/[IN] (UsOnly)
  • SAOJI, D., G. [IN]/[IN] (UsOnly)
  • AGARWAL, S., K. [IN]/[IN] (UsOnly)
  • DE SOUZA, N., J. [IN]/[IN] (UsOnly)
  • KHORAKIWALA, H., F. [IN]/[IN] (UsOnly)
Inventors
  • PATEL, M., V.
  • GUPTE, S., V.
  • CHUGH, Y.
  • SAOJI, D., G.
  • AGARWAL, S., K.
  • DE SOUZA, N., J.
  • KHORAKIWALA, H., F.
Agents
  • DE SOUZA, N., J.
Priority Data
60/170,67614.12.1999US
PCT/IN99/0001607.05.1999IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) (S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS
(FR) ACIDES CARBOXYLIQUES DE BENZOQUINOLIZINE ANTIBACTERIENS OPTIQUEMENT PURS, PROCEDES, COMPOSITIONS ET PROCEDES DE TRAITEMENT
Abstract
(EN) The present invention relates to S-(-)-optically pure benzoquinolizine carboxylic acid of formula I, and their pharmaceutically acceptable salts, derivatives, pseudopolymorphs, and hydrates, substantially free of their R-(+)-isomers, to processes for their preparation and to pharmaceutical compositions comprising an active compound of the invention. The compounds have excellent antibacterial activity. The compounds and compositions can be used for the treatment of local and systemic bacterial infections, diseases and disorders caused by antibiotic-sensitive and antibiotic-resistant microbial strains, without the concomitant liability of adverse effects associated with the racemic mixture of the active compound of the invention.
(FR) L'invention concerne des S-(-)- acides carboxyliques de benzoquinolizine optiquement purs de formule (I), y compris leurs sels pharmaceutiquement acceptables, dérivés, pseudopolymorphes et hydrates, sensiblement dépourvus de leurs R-(+)-isomères. L'invention concerne également des procédés relatifs à leur élaboration et des compositions pharmaceutiques renfermant un principe actif décrit dans l'invention. Les composés considérés ont une excellente activité antibactérienne. Les composés et les compositions en question peuvent être utilisés pour le traitement d'infections bactériennes locales et systémiques, de maladies et de troubles engendrés par des souches microbiennes sensibles et résistantes vis-à-vis des antibiotiques, sans risque concomitant d'effets préjudiciables associés au mélange racémique du principe actif décrit dans l'invention.
Related patent documents
ININ/PCT/2001/01369/MUMThis application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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