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1. (WO2000068221) SALTS OF 2,2-DIMETHYL-1,3-DIOXANE INTERMEDIATES AND PROCESS FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2000/068221 International Application No.: PCT/HU2000/000042
Publication Date: 16.11.2000 International Filing Date: 05.05.2000
Chapter 2 Demand Filed: 24.11.2000
IPC:
C07D 319/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
319
Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
04
1,3-Dioxanes; Hydrogenated 1,3-dioxanes
06
not condensed with other rings
Applicants:
KÓTAY NAGY, Péter [HU/HU]; HU (UsOnly)
GREFF, Zoltán [HU/HU]; HU (UsOnly)
BARKÓCZY, József [HU/HU]; HU (UsOnly)
SIMIG, Gyula [HU/HU]; HU (UsOnly)
BALÁZS, László [HU/HU]; HU (UsOnly)
DOMÁN, Imre [HU/HU]; HU (UsOnly)
RÁTKAI, Zoltán [HU/HU]; HU (UsOnly)
SERES, Péter [HU/HU]; HU (UsOnly)
BARTHA, Ferenc [HU/HU]; HU (UsOnly)
VERECZKEYNÉ DONÁTH, Györgyi [HU/HU]; HU (UsOnly)
NAGY, Kálmán [HU/HU]; HU (UsOnly)
EGIS GYÓGYSZERGYÁR RT. [HU/HU]; Keresztúri út 30-38 H-1106 Budapest, HU (AllExceptUS)
Inventors:
KÓTAY NAGY, Péter; HU
GREFF, Zoltán; HU
BARKÓCZY, József; HU
SIMIG, Gyula; HU
BALÁZS, László; HU
DOMÁN, Imre; HU
RÁTKAI, Zoltán; HU
SERES, Péter; HU
BARTHA, Ferenc; HU
VERECZKEYNÉ DONÁTH, Györgyi; HU
NAGY, Kálmán; HU
Agent:
ADVOPATENT; Office Of Patent And Trademark Attorneys P.O. Box 11 H-1251 Budapest, HU
Priority Data:
P990152606.05.1999HU
Title (EN) SALTS OF 2,2-DIMETHYL-1,3-DIOXANE INTERMEDIATES AND PROCESS FOR THE PREPARATION THEREOF
(FR) SELS D'INTERMEDIAIRES DE 2,2-DIMETHYL-1,3-DIOXANE ET LEUR PROCEDE DE PREPARATION
Abstract:
(EN) The invention relates to salts of (4R-cis) -(1,1-dimethyl -ethyl) -6-(2-aminoethyl) -2,2-dimethyl -1,3-dioxane -4-acetate of formula (I) formed with organic acids. The new salts according to the invention are stable and can be easily purified by recrystallization. The new salts of the invention are valuable pharmaceutical intermediates which can be used e.g. in the preparation of the hypolipidemic agent having the generic (INN) name atorvastatin. The invention further relates to the preparation of the new salts of the compound of formula (I).
(FR) L'invention concerne des sels de (4R-cis) -(1,1-diméthyl -éthyl) -6-(2-aminoéthyl) -2,2-diméthyl -1,3-dioxane -4-acétate de formule (I), ces sels étant formés avec des acides organiques. Les nouveaux sels de cette invention sont stables et aptes à être facilement purifiés par recristallisation. Les nouveaux sels de cette invention constituent par ailleurs de précieux intermédiaires pharmaceutiques pouvant être utilisés par exemple pour préparer un agent hypolipidémique ci-après dénommé atorvastatine (selon la dénomination DCI). Cette invention concerne enfin la préparation de nouveaux sels du composé de formule (I) susmentionné.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)