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1. (WO2000066603) HALO DERIVATIVES OF 9-DEOXO-9A-AZA-9A-HOMERYTHROMYCIN A
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2000/066603 International Application No.: PCT/HR2000/000013
Publication Date: 09.11.2000 International Filing Date: 02.05.2000
Chapter 2 Demand Filed: 30.11.2000
IPC:
C07H 17/08 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04
Heterocyclic radicals containing only oxygen as ring hetero atoms
08
Hetero rings containing eight or more ring members, e.g. erythromycins
Applicants:
MARUŠIĆ-IŠTUK, Zorica [HR/HR]; HR (UsOnly)
KUJUNDŽIĆ, Nedjelko [HR/HR]; HR (UsOnly)
KOBREHEL, Gabrijela [HR/HR]; HR (UsOnly)
MUTAK, Stjepan [HR/HR]; HR (UsOnly)
MARŠIĆ, Nataša [HR/HR]; HR (UsOnly)
PLIVA, FARMACEUTSKA INDUSTRIJA, DIONICKO DRUSTVO [HR/HR]; Ulica grada Vukovara 49 10000 Zagreb, HR (AllExceptUS)
Inventors:
MARUŠIĆ-IŠTUK, Zorica; HR
KUJUNDŽIĆ, Nedjelko; HR
KOBREHEL, Gabrijela; HR
MUTAK, Stjepan; HR
MARŠIĆ, Nataša; HR
Agent:
PLIVA, FARMACEUTSKA INDUSTRIJA, DIONICKO DRUSTVO; Pravni Poslovi Vesna Vasiljevic Ulica grada Vukovara 49 10000 Zagreb, HR
PLIVA D.D.; c/o Patentna Pisarna, d.o.o. Copova 14 P.O. Box 1725 1001 Ljubljana, SI
Common
Representative:
PLIVA, FARMACEUTSKA INDUSTRIJA, DIONICKO DRUSTVO; Pravni Poslovi Vesna Vasiljevic Ulica grada Vukovara 49 10000 Zagreb, HR
Priority Data:
P990130A03.05.1999HR
Title (EN) HALO DERIVATIVES OF 9-DEOXO-9A-AZA-9A-HOMERYTHROMYCIN A
(FR) DERIVES HALO DE 9-DESOXO-9A-AZA-9A-HOMOERYTHROMYCINE A
Abstract:
(EN) The invention relates to halo derivatives of 9a-$i(N)-($i(N')-arylcarbamoyl)- and 9a-$i(N)-($i(N')- arylthiocarbamoyl) -9- deoxo-9a-aza-9a-homoerythromycin A of general formula (I) wherein R has the meaning of a substituted aryl group of formula (II) wherein substituents a, b, c, d and e are the same or different and at least one of them has the meaning of halo, a(C1-C6)haloalkyl or a (C1-C6)haloalkoxy group, whereas the remaining ones have the meaning of hydrogen, halo, a (C1-C6)alkyl or a (C1-C6)alkoxy group, and X has the meaning of oxygen or sulfur, and pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to a process for the preparation, of pharmaceutical compositions comprising them and to the use of these pharmaceutical compositions for the treatment or prevention of bacterial infections.
(FR) L'invention se rapporte à des dérivés halo de 9a-$i(N)-($i(N')-arylcarbamoyl)- and 9a-$i(N)-($i(N')-arylthiocarbamoyl)-9-désoxo-9a-aza-9a-homoérythromycine A, représentés par la formule (I) dans laquelle R représente un groupe aryle substitué de formule (II) où les substituants a, b, c, d et e sont identiques ou différents et représentent, au moins pour l'un d'entre eux, un groupe halo, un groupe haloalkyle (C1-C6) ou haloalcoxy (C1-C6), tandis que les autres substituants représentent hydrogène, halo, un groupe alkyle (C1-C6) ou alcoxy (C1-C6), et X représente oxygène ou soufre. L'invention se rapporte également à des sels d'addition pharmaceutiquement acceptables de ces composés obtenus avec des acides inorganiques ou organiques. Elle se rapporte également à un procédé de préparation de compositions pharmaceutiques contenant ces composés ainsi qu'à l'utilisation de ces compositions pharmaceutiques pour le traitement ou la prévention d'infections bactériennes.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)