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Machine translation
1. (WO2000063395) NUCLEIC ACIDS ENCODING CD40/CD40L CHIMERIC POLYPEPTIDES, METHODS FOR THEIR PRODUCTION AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/063395    International Application No.:    PCT/EP2000/003318
Publication Date: 26.10.2000 International Filing Date: 13.04.2000
Chapter 2 Demand Filed:    22.07.2000    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/705 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; CH-4070 Basle (CH) (For All Designated States Except US).
DICKER, Frank [DE/DE]; (DE) (For US Only).
FRIESS, Thomas [DE/DE]; (DE) (For US Only).
MAASS, Gerd [DE/DE]; (DE) (For US Only).
PESSARA, Ulrich [DE/DE]; (DE) (For US Only).
SCHEUER, Werner [DE/DE]; (DE) (For US Only).
SEEBER, Stefan [DE/DE]; (DE) (For US Only)
Inventors: DICKER, Frank; (DE).
FRIESS, Thomas; (DE).
MAASS, Gerd; (DE).
PESSARA, Ulrich; (DE).
SCHEUER, Werner; (DE).
SEEBER, Stefan; (DE)
Agent: SCHREINER, Siegfried; Roche Diagnostics GmbH, Patent Department Pharma (TR-E), P.O. Box 11 52, D-82372 Penzberg (DE)
Priority Data:
99107611.8 16.04.1999 EP
99113967.6 17.07.1999 EP
Title (EN) NUCLEIC ACIDS ENCODING CD40/CD40L CHIMERIC POLYPEPTIDES, METHODS FOR THEIR PRODUCTION AND USES THEREOF
(FR) ACIDES NUCLEIQUES CODANT POUR DES POLYPEPTIDES CHIMERES CD40/CD40L, LEURS PROCEDES DE PRODUCTION ET LEURS UTILISATIONS
Abstract: front page image
(EN)A nucleic acid encoding a chimeric polypeptide comprising nucleic acid fragments encoding i) a mammalian signal peptide and downstream thereof, ii) the binding and trimerization domain of CD40L and downstream thereof, iii) a spacer of 50 to 100 amino acids and downstream thereof, iv) the transmembrane and signal transduction domains of CD40, is useful as a gene therapy agent for the local treatment of solid tumors.
(FR)Cette invention concerne un acide nucléique codant pour un polypeptide chimère comprenant des fragments d'acide nucléique codant pour: i) un peptide signal mammifère et ce qui en découle; ii) le domaine de liaison et de trimérisation de CD40L et ce qui en découle; iii) un espaceur de 50 à 100 acides aminés et ce qui en découle; iv) les domaines transmembranaires et de transduction de signal de CD40. Cet acide nucléique est utile comme agent de thérapie génique pour le traitement local des tumeurs solides.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)