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Pub. No.:    WO/2000/063372    International Application No.:    PCT/GB2000/001456
Publication Date: 26.10.2000 International Filing Date: 17.04.2000
Chapter 2 Demand Filed:    06.11.2000    
A61K 38/00 (2006.01), C07K 14/705 (2006.01)
Applicants: CELLTECH THERAPEUTICS LIMITED [GB/GB]; 216 Bath Road, Slough, Berkshire SL1 4EN (GB) (For All Designated States Except US).
LAWSON, Alastair, David, Griffiths [GB/GB]; (GB) (For US Only).
FINNEY, Helene, Margaret [GB/GB]; (GB) (For US Only)
Inventors: LAWSON, Alastair, David, Griffiths; (GB).
FINNEY, Helene, Margaret; (GB)
Agent: MERCER, Christopher, Paul; Carpmaels & Ransford, 43 Bloomsbury Square, London WC1A 2RA (GB)
Priority Data:
9908807.2 16.04.1999 GB
Abstract: front page image
(EN)The invention relates to synthetic signalling molecules, which are based on sequences derived from primary signalling motifs such as immunoglobulin tyrosine receptor-based activation motifs (ITAMs). The use of such signalling molecules within chimeric receptor proteins allows one to tailor the level of intracellular signalling mediated by the chimeric receptor. Proteins containing, and nucleic acids encoding, such synthetic signalling molecules suitable for use in medicine, are described.
(FR)Cette invention concerne des molécules de signalisation synthétiques, à base de séquences dérivées de motifs structuraux de signalisation primaires tels que les motifs d'activation à base de récepteurs d'immunoglobuline tyrosine (ITAM). L'utilisation de ces molécules de signalisation dans des protéines de récepteur chimérique permet d adapter le niveau de signalisation intracellulaire induit par le récepteur chimérique. Cette invention concerne aussi des protéines contenant ces molécules de signalisation synthétiques, et des acides nucléiques codant pour ces molécules, qui conviennent pour des utilisations médicales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)