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1. (WO2000063248) HIGHLY PURIFIED GONADOTROPIN COMPOSITIONS AND PROCESS FOR PREPARING THEM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/063248    International Application No.:    PCT/EP2000/003357
Publication Date: 26.10.2000 International Filing Date: 14.04.2000
Chapter 2 Demand Filed:    10.11.2000    
IPC:
A61K 38/00 (2006.01), C07K 14/59 (2006.01)
Applicants: INSTITUTO MASSONE S.A. [AR/AR]; Arias 4431, 1430 Buenos Aires (AR) (For All Designated States Except US).
WOLFENSON BAND, Claudio, Fernando [AR/AR]; (AR) (For US Only).
BALANIAN, Liliana, Ester [AR/AR]; (AR) (For US Only).
GROISMAN, José, Felipe [AR/AR]; (AR) (For US Only).
FASANELLA, Erundina, Marta [IT/AR]; (AR) (For US Only)
Inventors: WOLFENSON BAND, Claudio, Fernando; (AR).
BALANIAN, Liliana, Ester; (AR).
GROISMAN, José, Felipe; (AR).
FASANELLA, Erundina, Marta; (AR)
Agent: LONG, Giorgio; Jacobacci & Partners S.p.A., Via Senato, 8, I-20121 Milano (IT)
Priority Data:
60/129,540 16.04.1999 US
Title (EN) HIGHLY PURIFIED GONADOTROPIN COMPOSITIONS AND PROCESS FOR PREPARING THEM
(FR) COMPOSITIONS DE GONADOTROPHINES EXTREMEMENT PURIFIEES ET LEUR PROCEDE DE PREPARATION
Abstract: front page image
(EN)Purification process of human urinary gonadotropins of high biological activity and chemical purity absolutely free of foreign contaminating materials derived from the use of biological reagents or chromatography dyes, from crude of gonadotropins. The high biological activity and chemically pure composition of human gonadotropins obtained by this process, are used for the treatment of infertility and are selected from the group of follitropin or menotropins, having a bioactivity greater than 2500 IU/mg protein as tested by biological assay in rats, for both FSH and LH hormones for menotropins and greater than 5000 IU/mg protein for follitropin having an FSH:LH ratio about 75:1. Pharmaceutical preparations of said gonadotropins free of these contaminating materials are also comprised within the present invention.
(FR)Procédé de purification de gonadotrophines urinaires humaines présentant une activité biologique importante et une pureté chimique absolument exempte de matériaux étrangers contaminants provenant de l'utilisation de réactifs biologiques ou de colorants chromatographiques. On utilise cette composition biologiquement active et chimiquement pure de gonadotrophines humaines obtenue à partir d'urine brute afin de traiter la stérilité, ces gonadotrophines étant sélectionnées dans le groupe de follitrophine ou de ménotrophines, dont la bioactivité est supérieure à 2500 IU/mg de protéines, comme l'attestent des méthodes de détermination biologique chez le rat, à la fois pour les hormones FSH et LH en ce qui concerne les ménotrophines, et supérieure à 5000 IU/mg de protéines pour la follitrophine dont le rapport FSH :LH est égal à 75 :1. L'invention concerne également des préparation pharmaceutiques desdites gonadrotrophines exemptes de ces matériaux contaminants.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)