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Machine translation
1. (WO2000063246) COMPOUNDS AND METHODS FOR MODULATING BETA-CATENIN MEDIATED GENE EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/063246    International Application No.:    PCT/US2000/010753
Publication Date: 26.10.2000 International Filing Date: 21.04.2000
Chapter 2 Demand Filed:    20.11.2000    
IPC:
A61K 38/00 (2006.01), C07K 7/06 (2006.01), C07K 14/47 (2006.01)
Applicants: ADHEREX TECHNOLOGIES INC. [CA/CA]; Suite 340, 600 Peter Morand Crescent, Ottawa, Ontario K1G 5Z3 (CA) (For All Designated States Except US).
BLASCHUK, Orest, W. [CA/CA]; (CA) (For US Only).
BYERS, Stephen [GB/US]; (US) (For US Only).
GOUR, Barbara, J. [CA/CA]; (CA) (For US Only)
Inventors: BLASCHUK, Orest, W.; (CA).
BYERS, Stephen; (US).
GOUR, Barbara, J.; (CA)
Agent: MYLES, Gary; Seed Intellectual Property Law Group PLLC, Suite 6300, 701 Fifth Avenue, Seattle, WA 98104-7092 (US).
GOWSHALL,Jon V.,; FORRESTER & BOEHMERT,, Franz-Joseph-Str.38,, 80801 Munchen. (DE)
Priority Data:
09/296,089 21.04.1999 US
Title (EN) COMPOUNDS AND METHODS FOR MODULATING BETA-CATENIN MEDIATED GENE EXPRESSION
(FR) COMPOSES ET PROCEDES DE MODULATION DE L'EXPRESSION GENETIQUE PAR L'INTERMEDIAIRE DE LA BETA-CATENINE
Abstract: front page image
(EN)Modulating agents for inhibiting $g(b)-catenin mediated gene expression are provided. The modulating agents comprise one or more of: (1) the peptide sequence LXXLL (SEQ ID NO:1); or (2) a peptide analogue or peptidomimetic thereof. Methods for using such modulating agents for modulating $g(b)-catenin mediated gene expression and cellular differentiation in a variety of contexts (e.g., for modulating hair growth or treating cancer or Alzheimer's disease) are provided.
(FR)La présente invention concerne des agents de modulation pour l'inhibition de l'expression génétique par l'intermédiaire de $g(b)-caténine. Les agents modulateurs comprennent un ou plusieurs des éléments suivants: (1) la séquence peptidique LXXLL (SEQ.ID NO. 1); ou (2) un peptide analogue ou peptidomimétique de celle-ci. L'invention concerne également des procédés d'utilisation de tels agents modulateurs dans la modulation de l'expression génétique par l'intermédiaire de $g(b)-caténine et la différenciation cellulaire dans divers contextes (par exemple, pour la modulation de la croissance des cheveux ou le traitement du cancer ou de la maladie d'Alzheimer).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)