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1. (WO2000063245) VARIANT OF THE PLASMODIUM MEROZOITE SURFACE PROTEIN (MSP-1) AND VACCINE COMPRISING SAID VARIANT

Pub. No.:    WO/2000/063245    International Application No.:    PCT/GB2000/001558
Publication Date: Oct 26, 2000 International Filing Date: Apr 20, 2000
IPC: A61K 38/00
A61K 39/00
A61K 48/00
C07K 14/445
Applicants: MEDICAL RESEARCH COUNCIL
HOLDER, Anthony
BIRDSALL, Berry
FEENEY, James
MORGAN, William
SYED, Shabih
UTHAIPIBULL, Chairat
Inventors: HOLDER, Anthony
BIRDSALL, Berry
FEENEY, James
MORGAN, William
SYED, Shabih
UTHAIPIBULL, Chairat
Title: VARIANT OF THE PLASMODIUM MEROZOITE SURFACE PROTEIN (MSP-1) AND VACCINE COMPRISING SAID VARIANT
Abstract:
A non-naturally occurring variant of a C-terminal fragment of a Plasmodium merozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurring Plasmodium MSP-119, for at least one first antibody capable of blocking the binding of a second antibody, which second antibody inhibits the proteolytic cleavage of Plasmodium MSP-142 and (ii) substantially the same affinity for at least one third antibody compared with said naturally occurring Plasmodium MSP-119, which third antibody inhibits the proteolytic cleavage of Plasmodium MSP-142 is provided for use in an anti-malarial vaccine.