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1. (WO2000063223) NOVEL 8A- AND 9A-15-MEMBERED LACTAMS

Pub. No.:    WO/2000/063223    International Application No.:    PCT/HR2000/000009
Publication Date: Fri Oct 27 01:59:59 CEST 2000 International Filing Date: Thu Apr 20 01:59:59 CEST 2000
IPC: C07H 17/08
Applicants: PLIVA, FARMACEUTSKA INDUSTRIJA, DIONICKO DRUSTVO
LAZAREVSKI, Gorjana
ALIHODžIć, Sulejman
KOBREHEL, Gabrijela
MUTAK, Stjepan
Inventors: LAZAREVSKI, Gorjana
ALIHODžIć, Sulejman
KOBREHEL, Gabrijela
MUTAK, Stjepan
Title: NOVEL 8A- AND 9A-15-MEMBERED LACTAMS
Abstract:
The invention relates to novel 15-membered 8a- and 9a-lactams from the class of 6-O-methyl-erythromycin A of general formula (I), their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, wherein A stands for NH group and B simultaneously stands for C=O group, or A stands for C=O group and B simultaneously stands for NH group, and the radicals R?1, R2, R3, R4, R5, R6¿ have the meaning given in claim 1.