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1. WO2000063223 - NOVEL 8A- AND 9A-15-MEMBERED LACTAMS

Publication Number WO/2000/063223
Publication Date 26.10.2000
International Application No. PCT/HR2000/000009
International Filing Date 19.04.2000
Chapter 2 Demand Filed 16.11.2000
IPC
C07H 17/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
CPC
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
C07H 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
Applicants
  • PLIVA, FARMACEUTSKA INDUSTRIJA, DIONICKO DRUSTVO [HR]/[HR] (AllExceptUS)
  • LAZAREVSKI, Gorjana [HR]/[HR] (UsOnly)
  • ALIHODŽIĆ, Sulejman [HR]/[HR] (UsOnly)
  • KOBREHEL, Gabrijela [HR]/[HR] (UsOnly)
  • MUTAK, Stjepan [HR]/[HR] (UsOnly)
Inventors
  • LAZAREVSKI, Gorjana
  • ALIHODŽIĆ, Sulejman
  • KOBREHEL, Gabrijela
  • MUTAK, Stjepan
Agents
  • PLIVA D.D. PRAVNI POSLOVI
Priority Data
P990116A20.04.1999HR
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL 8A- AND 9A-15-MEMBERED LACTAMS
(FR) NOUVEAUX LACTAMES 8A ET 9A A 15 ELEMENTS
Abstract
(EN) The invention relates to novel 15-membered 8a- and 9a-lactams from the class of 6-$i(O)-methyl-erythromycin A of general formula (I), their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, wherein A stands for NH group and B simultaneously stands for C=O group, or A stands for C=O group and B simultaneously stands for NH group, and the radicals R1, R2, R3, R4, R5, R6 have the meaning given in claim 1.
(FR) La présente invention concerne de nouveaux lactames 8a et 9a à 15 éléments issus de la classe du composé 6-$i(O)-méthyl-érythromycine A de formule (I), leurs sels d'addition pharmaceutiquement acceptables avec des acides organiques ou inorganiques et leurs hydrates. Dans la formule (I), A représente un groupe NH et B représente simultanément un groupe C=O, ou A représente un groupe C=O et B représente simultanément un groupe NH ; les radicaux R1, R2, R3, R4, R5 et R6 correspondent à la signification donnée dans la revendication 1.
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