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1. (WO2000063202) BENZO[b] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE DERIVATIVES AND THEIR USE AS ANTINEOPLASTIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/063202    International Application No.:    PCT/IB2000/000563
Publication Date: 26.10.2000 International Filing Date: 14.04.2000
Chapter 2 Demand Filed:    27.10.2000    
IPC:
C07D 333/54 (2006.01)
Applicants: UNIVERSIDAD PUBLICA DE NAVARRA [ES/ES]; Campus Arrosadia, OTRI (Edif. el Sario), E-31006 Pamplona (ES) (For All Designated States Except US).
MARTINEZ MERINO, Victor [ES/ES]; (ES) (For US Only).
GIL IDOATE, Maria Jose [ES/ES]; (ES) (For US Only).
ENCIO MARTINEZ, Ignacio [ES/ES]; (ES) (For US Only).
MIGLIACCIO VAZQUEZ, Marco [ES/ES]; (ES) (For US Only).
ARTEAGA MARTIN, Carmen [ES/ES]; (ES) (For US Only)
Inventors: MARTINEZ MERINO, Victor; (ES).
GIL IDOATE, Maria Jose; (ES).
ENCIO MARTINEZ, Ignacio; (ES).
MIGLIACCIO VAZQUEZ, Marco; (ES).
ARTEAGA MARTIN, Carmen; (ES)
Agent: ENGLAND, Christopher, David; BTG International Limited, 10 Fleet Place, Limeburner Lane, London EC4M 7SB (GB)
Priority Data:
P 9900883 19.04.1999 ES
Title (EN) BENZO[b] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE DERIVATIVES AND THEIR USE AS ANTINEOPLASTIC AGENTS
(FR) DERIVES DE BENZO[$i(b)] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE ET LEUR UTILISATION COMME AGENTS ANTINEOPLASIQUES
Abstract: front page image
(EN)Compounds of formula (I) or (II) wherein: n is 1 or 2; R¿4? and R¿5? each represents hydrogen or C¿1?-C¿3? alkyl; and each R may be in position 4, 5, 6, or 7 of the benzothiophene ring and independently represents hydrogen; a halogen; C¿1?-C¿3? alkyl; or a group -SO¿2?Y, in whch Y represents a group -NR¿1?R¿2?, a group -NHCOOR¿3?, -NHCONH¿2? or a group -NHCONHR¿3? in which R¿1? and R¿2? are independently hydrogen, C¿1?-C¿3? alkyl or aryl, and R¿3? is C¿1?-C¿3? alkyl or aryl; with the proviso that one and only one R represents a group -SO¿2?Y; are useful in the treatment of cancerous tumours.
(FR)La présente invention concerne les composés de la formule (I) ou (II) dans lesquelles: n représente 1 ou 2; R¿4? et R¿5? représentent chacun hydrogène ou C¿1?-C¿3? alkyle; et chaque R peut être en position 4, 5, 6, ou 7 du noyau benzothiophène et représente individuellement hydrogène; un halogène; C¿1?-C¿3? alkyle; ou un groupe -SO¿2?Y, dans lequel Y représente un groupe NR¿1?R¿2?, un groupe -NHCOOR¿3?, -NHCONH¿2? ou un groupe NHCONHR¿3? dans lequel R¿1? et R¿2? représentent individuellement hydrogène, C¿1?-C¿3? alkyle ou aryle, et R¿3? représente C¿1?-C¿3? alkyle ou aryle; sous réserve qu'un seul et unique R représente un groupe -SO¿2?Y; ces composés étant utilisés dans le traitement des tumeurs cancéreuses.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)