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Machine translation
1. (WO2000061780) COMPOSITIONS AND METHODS FOR EXTENDING LIFE SPAN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/061780    International Application No.:    PCT/US2000/009209
Publication Date: 19.10.2000 International Filing Date: 08.04.2000
Chapter 2 Demand Filed:    07.11.2000    
IPC:
A61K 48/00 (2006.01), C12N 9/12 (2006.01), C12Q 1/48 (2006.01)
Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY [US/US]; Liberty Plaza, 335 George Street, New Brunswick, NJ 08903-2688 (US) (For All Designated States Except US).
RYAZANOV, Alexey G. [US/US]; (US) (For US Only).
TAVERNARAKIS, Kektarios [US/US]; (US) (For US Only).
DRISCOLL, Monica [US/US]; (US) (For US Only).
PAVUR, Karen [US/US]; (US) (For US Only).
NEFSKY, Bradley [US/US]; (US) (For US Only)
Inventors: RYAZANOV, Alexey G.; (US).
TAVERNARAKIS, Kektarios; (US).
DRISCOLL, Monica; (US).
PAVUR, Karen; (US).
NEFSKY, Bradley; (US)
Agent: REED, Janet, E.; Saul Ewing LLP, Centre Square West, 1500 Market Street, Philadelphia, PA 19102 (US)
Priority Data:
60/128,397 08.04.1999 US
Title (EN) COMPOSITIONS AND METHODS FOR EXTENDING LIFE SPAN
(FR) COMPOSITIONS ET TECHNIQUES PERMETTANT D'ALLONGER LA DUREE DE VIE
Abstract: front page image
(EN)Specific inhibition of EF-2 kinase results in the significant extension of life span without any adverse effects on behavior, development, and reproduction. Moreover, inhibition of this enzyme decreases the rate of aging and results in a more than two-fold increase in the sexually-active period of the life span. Inhibition of the activity of the enzyme results in increased overall protein turnover, which is positively correlated with the decrease in rate of aging and increase in life span.
(FR)L'inhibition spécifique de la EF-2 kinase produit un allongement significatif de la durée de vie sans effets indésirables sur le comportement, le développement, et la reproduction. En outre, l'inhibition de cet enzyme ralentit le vieillissement, et multiplie au moins par deux la période d'activité sexuelle. L'inhibition de l'activité de l'enzyme allonge le cycle de reconstitution protonique global, ce qui est corrélé positivement par le ralentissement du vieillissement et l'allongement de la durée de vie.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)