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Machine translation
1. (WO2000061761) RECOMBINANT CLOSTRIDIUM TOXIN A PROTEIN CARRIER FOR POLYSACCHARIDE CONJUGATE VACCINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/061761    International Application No.:    PCT/US2000/009523
Publication Date: 19.10.2000 International Filing Date: 10.04.2000
Chapter 2 Demand Filed:    09.11.2000    
IPC:
A61K 38/00 (2006.01), A61K 39/08 (2006.01), C07K 14/33 (2006.01)
Applicants: TECHLAB, INC. [US/US]; 1861 Pratt Drive, Blacksburg, VA 24060-6364 (US).
DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health, 6011 Executive Blvd, Bethesda, MD (US)
Inventors: WILKINS, Tracy, D.; (US).
LYLERLY, David, M.; (US).
MONCRIEF, J., Scott; (US).
PAVLIAKOVA, Danka; (US).
SCHEERSON, Rachel; (US).
ROBBINS, John, B.; (US)
Agent: MAYS, Thomas, D.; Morrison & Foerster LLP, 2000 Pennsylvania Avenue, N.W., Washington, DC 20006-1888 (US).
GOLDIN Douglas Michael; J.A. Kemp & Co, 14 South Square,, Gray's Inn,, London WC1R 5LX (GB)
Priority Data:
60/128,686 09.04.1999 US
60/186,201 01.03.2000 US
Title (EN) RECOMBINANT CLOSTRIDIUM TOXIN A PROTEIN CARRIER FOR POLYSACCHARIDE CONJUGATE VACCINES
(FR) SUPPORT PROTEIQUE RECOMBINANT DE LA TOXINE A POUR VACCINS CONJUGUES POLYSACCHARIDES
Abstract: front page image
(EN)The present invention provides for immunogenic compositions and their methods of use as vaccines and their method of preparation. These immunogenic compositions comprise a recombinant protein of toxin A of Clostridium difficile conjugated to a polysaccharide of a microbial pathogen. The immunogenic compositions may include only a truncated portion of toxin A, particularly the repeating units (rARU), that is conjugated to a microbial pathogen polysaccharide. Such compositions are effective in eliciting T-cell dependent and antibody responses. These compositions are therefore effective as vaccines for humans, particularly children, and animals in affording protection against one or more microbial pathogens.
(FR)La présente invention concerne des compositions immunogènes, leurs procédés d'utilisation comme vaccins et leurs procédés de préparation. Ces compositions immunogènes contiennent une protéine recombinante de la toxine A de $i(Clostridium difficile), conjuguée à un polysaccharide d'un pathogène microbien. Les compositions immunogènes peuvent contenir uniquement une partie tronquée de la toxine A, en particulier les unités récurrentes ($i(r)ARU), conjuguée à un polysaccharide de pathogène microbien. De telles compositions sont efficaces pour induire une réponse dépendant des lymphocytes T ou anticorps. Ces compositions sont par conséquent efficaces en tant que vaccins destinés à l'homme, en particulier à l'enfant, et aux animaux, contre un ou plusieurs pathogènes microbiens.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)