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Machine translation
1. (WO2000061613) CHANNEL FORMING TOXINS AS ANTIVIRAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/061613    International Application No.:    PCT/US2000/009468
Publication Date: 19.10.2000 International Filing Date: 10.04.2000
Chapter 2 Demand Filed:    07.11.2000    
IPC:
A61K 38/16 (2006.01), A61K 39/21 (2006.01), C12N 7/06 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; Suite 906, 111 Market Place, Baltimore, MD 21202 (US) (For All Designated States Except US).
UNIVERSITY OF VICTORIA [CA/CA]; P.O. Box 3075, R hut, McKrnzie Avenue, Victoria, British Columbia V8W 3W2 (CA) (For All Designated States Except US).
HILDRETH, James, E., K. [US/US]; (US) (For US Only).
NGUYEN, Dzung, H., B., S. [US/US]; (US) (For US Only).
BUCKLEY, James, Thomas [CA/CA]; (CA) (For US Only)
Inventors: HILDRETH, James, E., K.; (US).
NGUYEN, Dzung, H., B., S.; (US).
BUCKLEY, James, Thomas; (CA)
Agent: KAGAN, Sarah, A.; Banner & Witcoff, Ltd., 11th floor, 1001 G Street, N.W., Washington, DC 20001-4597 (US)
Priority Data:
60/128,541 09.04.1999 US
Title (EN) CHANNEL FORMING TOXINS AS ANTIVIRAL AGENTS
(FR) TOXINES FORMANT DES CANAUX EN TANT QU'ANTIVIRAUX
Abstract: front page image
(EN)The infectivity of a population of enveloped viruses which comprise a glycosylphosphatidylinositol-anchored protein in their membrane can be reduced by employing certain toxins such as aerolysin, alpha toxin of Clostridium septicum, or enterolobin. Toxins which bind to glycosylphosphatidylinositol-anchored proteins inactivate such viruses. The toxins can be used to produce attenuated viral vaccines, to purge blood products, cells, or tissues of such viruses, and to detect viruses in samples.
(FR)Pour diminuer l'infectivité d'une population de virus enveloppés qui comprennent une protéine ancrée à glycosylphosphatidylinositol dans leur membrane, on utilise certaines toxines telles que l'aérolysine, la toxine alpha de $i(Clostridium septicum) ou l'entérolobine. Les toxines qui se lient à des protéines ancrées à glycosylphosphatidylinositol inactivent ces virus. Ces toxines peuvent servir à produire des vaccins viraux atténués, à purger des produits sanguins, des cellules ou des tissus desdits virus et à détecter lesdits virus dans des échantillons.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)