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1. (WO2000061602) ANTISENSE OLIGONUCLEOTIDE MODULATION OF STAT3 EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/061602    International Application No.:    PCT/US2000/009054
Publication Date: 19.10.2000 International Filing Date: 06.04.2000
Chapter 2 Demand Filed:    30.10.2000    
IPC:
A61K 38/00 (2006.01), C12N 15/11 (2006.01)
Applicants: ISIS PHARMACEUTICALS, INC. [US/US]; 2292 Faraday Avenue, Carlsbad, CA 92008 (US) (For All Designated States Except US).
KARRAS, James, G. [US/US]; (US) (For US Only)
Inventors: KARRAS, James, G.; (US)
Agent: LICATA, Jane, Massey; Law Offices of Jane Massey Licata, 66 E. Main Street, Marlton, NJ 08053 (US)
Priority Data:
09/288,461 08.04.1999 US
Title (EN) ANTISENSE OLIGONUCLEOTIDE MODULATION OF STAT3 EXPRESSION
(FR) MODULATION DE L'EXPRESSION DES STAT3, AU MOYEN D'OLIGONUCLEOTIDES ANTISENS
Abstract: front page image
(EN)Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
(FR)L'invention concerne des composés, des compositions et des méthodes pour l'inhibition de l'expression des STAT3 humains. Lesdites compositions comprennent des oligonucléotides antisens dirigés contre des acides nucléiques codant pour STAT3. Des méthodes d'utilisation desdits nucléotides pour l'inhibition de l'expression de STAT3 et pour la promotion de l'apoptose sont décrites, ainsi que des méthodes de traitement de maladies, notamment de maladies inflammatoires et de cancers, associés à la surexpression ou à l'activation constitutive de STAT3 ou l'apoptose insuffisante.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)