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1. (WO2000061600) ANTISENSE MODULATION OF SMAD3 EXPRESSION

Pub. No.:    WO/2000/061600    International Application No.:    PCT/US1999/025306
Publication Date: Oct 19, 2000 International Filing Date: Oct 27, 1999
IPC: A61K 38/00
C12N 15/11
Applicants: ISIS PHARMACEUTICALS, INC.
MONIA, Brett, P.
COWSERT, Lex, M.
Inventors: MONIA, Brett, P.
COWSERT, Lex, M.
Title: ANTISENSE MODULATION OF SMAD3 EXPRESSION
Abstract:
Antisense compounds, compositions and methods are provided for modulating the expression of Smad3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Smad3. Methods of using these compounds for modulation of Smad3 expression and for treatment of diseases associated with expression of Smad3 are provided.