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Machine translation
1. (WO2000061577) PRODRUGS OF THROMBIN INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/061577    International Application No.:    PCT/EP2000/003008
Publication Date: 19.10.2000 International Filing Date: 05.04.2000
Chapter 2 Demand Filed:    02.09.2000    
IPC:
A61K 38/00 (2006.01), C07B 43/00 (2006.01), C07D 401/12 (2006.01), C07K 5/065 (2006.01)
Applicants: BASF AKTIENGESELLSCHAFT [DE/DE]; D-67056 Ludwigshafen (DE) (For All Designated States Except US).
BAUCKE, Dorit [DE/DE]; (DE) (For US Only).
MACK, Helmut [DE/DE]; (DE) (For US Only).
SEITZ, Werner [DE/DE]; (DE) (For US Only).
HORNBERGER, Wilfried [DE/DE]; (DE) (For US Only).
BACKFISCH, Gisela [DE/DE]; (DE) (For US Only).
DELZER, Jürgen [DE/DE]; (DE) (For US Only)
Inventors: BAUCKE, Dorit; (DE).
MACK, Helmut; (DE).
SEITZ, Werner; (DE).
HORNBERGER, Wilfried; (DE).
BACKFISCH, Gisela; (DE).
DELZER, Jürgen; (DE)
Common
Representative:
BASF AKTIENGESELLSCHAFT; D-67056 Ludwigshafen (DE)
Priority Data:
199 15 930.0 09.04.1999 DE
100 06 799.9 15.02.2000 DE
Title (DE) PRODRUGS VON THROMBININHIBITOREN
(EN) PRODRUGS OF THROMBIN INHIBITORS
(FR) PROMEDICAMENTS D'INHIBITEURS DE LA THROMBINE
Abstract: front page image
(DE)Die vorliegende Erfindung betrifft Prodrugs der allgemeinen Formel (I), deren Bedeutung in der Beschreibung angegeben ist. Diese Prodrugs von pharmakologisch wirksamen, heterocyclischen Amidinen, aus denen in vivo Verbindungen entstehen, welche kompetitive Inhibitoren von Trypsin-ähnlichen Serinproteasen, besonders Thrombin sind, ihre Herstellung und ihre Verwendung als Medikamente, werden beschrieben.
(EN)The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
(FR)La présente invention concerne des promédicaments de formule générale (I) dont la signification est donnée dans la description de l'invention. Cette invention concerne les promédicaments d'amidines hétérocycliques, pharmaceutiquement actives, à partir desquelles des composés sont produits $i(in vivo), lesdits composés constituant des inhibiteurs compétitifs des sérines protéases du type trypsine, notamment de la thrombine. De plus, l'invention concerne la production de ces promédicaments et leur utilisation en tant que médicaments.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)