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1. WO2000061571 - 4,5-DIARYL-3($i(2H))-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS

Publication Number WO/2000/061571
Publication Date 19.10.2000
International Application No. PCT/KR2000/000339
International Filing Date 12.04.2000
Chapter 2 Demand Filed 02.11.2000
IPC
C07D 307/58 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02not condensed with other rings
34having two or three double bonds between ring members or between ring members and non-ring members
56with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
58One oxygen atom, e.g. butenolide
C07D 307/94 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
94spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
C07D 405/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 407/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 409/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 493/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • PACIFIC CORPORATION [KR]/[KR] (AllExceptUS)
  • SHIN, Song, Seok [KR]/[KR] (UsOnly)
  • NOH, Min-Soo [KR]/[KR] (UsOnly)
  • BYUN, Young, Joo [KR]/[KR] (UsOnly)
  • CHOI, Jin, Kyu [KR]/[KR] (UsOnly)
  • KIM, Jin, Kwan [KR]/[KR] (UsOnly)
  • LIM, Kyung, Min [KR]/[KR] (UsOnly)
  • KIM, Ji, Young [KR]/[KR] (UsOnly)
  • CHOI, Young, Hoon [KR]/[KR] (UsOnly)
  • HA, Jun-Yong [KR]/[KR] (UsOnly)
  • LEE, Ki-Wha [KR]/[KR] (UsOnly)
  • MOH, Joo, Hyun [KR]/[KR] (UsOnly)
  • JEONG, Yeon, Su [KR]/[KR] (UsOnly)
  • CHUNG, Shin [KR]/[KR] (UsOnly)
  • JOO, Yung, Hyup [KR]/[KR] (UsOnly)
  • LEE, Chang, Hoon [KR]/[KR] (UsOnly)
  • KANG, Seon, Hwa [KR]/[KR] (UsOnly)
  • PARK, Young-Ho [KR]/[KR] (UsOnly)
  • YI, Jung, Bum [KR]/[KR] (UsOnly)
Inventors
  • SHIN, Song, Seok
  • NOH, Min-Soo
  • BYUN, Young, Joo
  • CHOI, Jin, Kyu
  • KIM, Jin, Kwan
  • LIM, Kyung, Min
  • KIM, Ji, Young
  • CHOI, Young, Hoon
  • HA, Jun-Yong
  • LEE, Ki-Wha
  • MOH, Joo, Hyun
  • JEONG, Yeon, Su
  • CHUNG, Shin
  • JOO, Yung, Hyup
  • LEE, Chang, Hoon
  • KANG, Seon, Hwa
  • PARK, Young-Ho
  • YI, Jung, Bum
Agents
  • YOON, Dong-Yol
Priority Data
1999/1317014.04.1999KR
1999/2977922.07.1999KR
1999/3904313.09.1999KR
2000/1686631.03.2000KR
2000/1764704.04.2000KR
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 4,5-DIARYL-3($i(2H))-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS
(FR) DERIVES DE 4,5-DIARYL-3($i(2H))-FURANONE COMME INHIBITEURS DE CYCLO-OXYGENASE-2
Abstract
(EN) The present invention provides a novel class of 4,5-diaryl-3($i(2H))-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.
(FR) La présente invention concerne une nouvelle classe de dérivés de 4,5-diaryl-3($i(2H))-furanone, qui inhibent fortement et de manière sélective la COX-2 par rapport à la COX-1. Ces dérivés sont utiles pour traiter l'inflammation, des affections associées à l'inflammation et des maladies dépendant de COX-2.
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