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1. (WO2000061151) OLIGODEOXYNUCLEOTIDE AND ITS USE TO INDUCE AN IMMUNE RESPONSE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2000/061151 International Application No.: PCT/US2000/009839
Publication Date: 19.10.2000 International Filing Date: 12.04.2000
Chapter 2 Demand Filed: 08.11.2000
IPC:
A61K 31/7088 (2006.01) ,A61K 39/008 (2006.01) ,A61K 39/39 (2006.01) ,A61K 45/06 (2006.01) ,C07H 21/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
08
Clostridium, e.g. Clostridium tetani
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applicants:
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard Suite 325 Rockville, MD 20852, US (AllExceptUS)
KLINMAN, Dennis [US/US]; US (UsOnly)
ISHII, Ken [JP/US]; US (UsOnly)
VERTHELYI, Daniela [AR/US]; US (UsOnly)
Inventors:
KLINMAN, Dennis; US
ISHII, Ken; US
VERTHELYI, Daniela; US
Agent:
GAGALA, Bruce, M. ; Leydig, Voit & Mayer, Ltd. Suite 4900 Two Prudential Plaza, 180 North Stetson Chicago, IL 60601-6780, US
Priority Data:
60/128,89812.04.1999US
Title (EN) OLIGODEOXYNUCLEOTIDE AND ITS USE TO INDUCE AN IMMUNE RESPONSE
(FR) UN OLIGODESOXYNUCLEOTIDE ET SON EMPLOI POUR INDUIRE UNE REPONSE IMMUNITAIRE
Abstract:
(EN) The present invention provides a substantially pure or isolated oligodeoxynucleotide of at least about 10 nucleotides comprising a sequence represented by either the formula: 5' N1N2N3T-CpG-WN4N5N6 3' wherein the central CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are any ncleotides, or the formula: 5' RY-CpG-RY 3' wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host.
(FR) L'invention concerne un oligodésoxynucléotide sensiblement pur ou isolé d'au moins une dizaine de nucléotides comprenant une séquence représentée soit par la formule 5' N1N2N3T-CpG-WN4N5N6 3', dans laquelle le motif central CpG est non méthylé, W représente A ou T, et N1, N2, N3, N4, N5 et N6 représentent des nucléotides, soit par la formule 5' RY-CpG-RY 3', dans laquelle le motif central CpG est non méthylé, R représente A ou G, et Y représente C ou T, ainsi qu'un complexe d'administration d'oligodésoxynucléotide et une composition pharmaceutique contenant ledit oligodésoxynucléotide. L'invention traite également d'un procédé destiné à induire une réponse immunitaire par administration dudit oligodésoxynucléotide à un hôte.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)