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1. (WO2000061132) COMPOSITIONS CONTAINING IMMUNOTOXINS AND AGENTS THAT INHIBIT DENDRITIC CELL MATURATION FOR INDUCING IMMUNE TOLERANCE TO A GRAFT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/061132    International Application No.:    PCT/US2000/010253
Publication Date: 19.10.2000 International Filing Date: 14.04.2000
Chapter 2 Demand Filed:    14.11.2000    
IPC:
A61K 39/395 (2006.01), A61K 47/48 (2006.01), A61K 49/00 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer, Suite 325, 6011 Executive Boulevard, Rockville, MD 20852 (US) (For All Designated States Except US).
THE UAB RESEARCH FOUNDATION [US/US]; 1120-G Administrative Building, 701 South 20th Street, Suite 1120-G, Birmingham, AL 35294-0111 (US) (For All Designated States Except US).
NEVILLE, David, M. [US/US]; (US) (For US Only).
THOMAS, Judith, M. [US/US]; (US) (For US Only)
Inventors: NEVILLE, David, M.; (US).
THOMAS, Judith, M.; (US)
Agent: SPRATT, Gwendolyn, D.; Needle & Rosenberg, P.C., Suite 1200, 127 Peachtree Street, N.E., Atlanta, GA 30303-1811 (US).
LEIßLER-GERSTL, Gabriele; Eisenführ, Speiser & Partner, Arnulfstrasse 25, 80335 München (DE)
Priority Data:
09/291,712 14.04.1999 US
Title (EN) COMPOSITIONS CONTAINING IMMUNOTOXINS AND AGENTS THAT INHIBIT DENDRITIC CELL MATURATION FOR INDUCING IMMUNE TOLERANCE TO A GRAFT
(FR) COMPOSITIONS CONTENANT DES IMMUNOTOXINES ET DES AGENTS INHIBITEURS DE MATURATION DE CELLULE DENDRITIQUE PERMETTANT D'INDUIRE UNE TOLERANCE IMMUNITAIRE DANS UNE GREFFE
Abstract: front page image
(EN)The present invention provides a method of inducing immune tolerance to a graft in a recipient, comprising administering to the recipient an immunotoxin, thereby reducing the recipient's T-cell population; and administering to the recipient an agent that inhibits dendritic cell maturation. The present invention also provides a method of screening for an agent that acts synergistically with an immunotoxin in inducing immune tolerance and a method of screening for an agent that inhibits dendritic cell maturation. The present invention also provides a method of treating a subject with an autoimmune disease, comprising administering to the subject an immunotoxin, thereby reducing the subject's T-cell population; and administering to the subject an agent that inhibits dendritic cell maturation. Also provided herein is a composition comprising an immunotoxin and an agent that inhibits dendritic cell maturation.
(FR)La présente invention concerne une méthode destinée à induire une tolérance immunitaire dans une greffe et consistant à administrer au receveur une immunotoxine, réduisant ainsi sa population de lymphocytes T, puis à lui administrer un agent inhibiteur de maturation de cellule dendritique. La présente invention concerne également une méthode de criblage d'un agent agissant de façon synergistique avec une immunotoxine pour induire une tolérance immunitaire, ainsi qu'une méthode de criblage d'un agent inhibiteur de maturation de cellule dendritique. La présente invention concerne également une méthode de traitement d'un sujet atteint d'une maladie auto-immune, consistant à administrer au sujet une immunotoxine, réduisant ainsi sa population de lymphocytes T du sujet, puis à lui administrer un agent inhibiteur de maturation de cellule dendritique. L'invention concerne enfin une composition comprenant une immunotoxine et un agent inhibiteur de maturation de cellule dendritique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)