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Machine translation
1. (WO2000061118) ANHYDROUS TABLET OF RANITIDINE HYDROCHLORIDE WITH DOUBLE-LAYER COATING AND ITS COMPOSITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/061118    International Application No.:    PCT/EP2000/003330
Publication Date: 19.10.2000 International Filing Date: 11.04.2000
Chapter 2 Demand Filed:    03.10.2000    
IPC:
A61K 9/20 (2006.01), A61K 9/28 (2006.01)
Applicants: PHARMEXCEL SRL [IT/IT]; Via dei Grimani, 10, I-20144 Milano (IT) (For All Designated States Except US).
VERONESI, Paolo, Alberto [IT/IT]; (IT) (For US Only).
PESCHECHERA, Emanuela [IT/IT]; (IT) (For US Only).
CIRERA DOTTI, Xavier [ES/ES]; (ES) (For US Only)
Inventors: VERONESI, Paolo, Alberto; (IT).
PESCHECHERA, Emanuela; (IT).
CIRERA DOTTI, Xavier; (ES)
Agent: MICHELOTTI, Giuliano; Galleria San Babila, 4/C, I-20122 Milano (IT)
Priority Data:
MI99A000740 12.04.1999 IT
Title (EN) ANHYDROUS TABLET OF RANITIDINE HYDROCHLORIDE WITH DOUBLE-LAYER COATING AND ITS COMPOSITION
(FR) COMPRIME ANHYDRE D'HYDROCHLORURE DE RANITIDINE AVEC ENROBAGE DOUBLE COUCHE ET SA COMPOSITION
Abstract: front page image
(EN)The invention concerns an anhydrous tablet containing anhydrous ranitidine hydrochloride, coated by a double-layer coating, its composition and the relevant process of preparation. The anhydrous tablet of the invention is characterized by the direct dry tabletting, without using water, of a mixture consisting of the active ingredient anhydrous ranitidine hydrochloride, in the crystalline form 'allomorphous Form 1' having a particular purity and stability, and by a global amount of other excipients and adjuvant substances or inert vehicles less than the weight of the active ingredient. Moreover, the anhydrous tablet of the invention is characterized by a high percentage of disintegrating substance in the tabletting mixture and by a special two-layer coating.
(FR)Cette invention concerne un comprimé anhydre renfermant un hydrochlorure de ranitidine anhydre, à enrobage double couche, ainsi que la composition de ce comprimé et sa méthode de fabrication. Le comprimé anhydre selon l'invention se caractérise par le moulage direct à sec, sans eau, d'un mélange composé du principe actif représenté par l'hydrochlorure de ranitidine anhydre sous la forme cristalline « Forme 1 allomorphe », à la pureté et à la stabilité particulières, et d'une dose globale d'autres excipients et substances adjuvante ou véhicules inertes d'un poids inférieur à celui du principe actif. De plus, ce comprimé anhydre l'invention se distingue par une forte teneur en substance désintégrante dans le mélange moulé et par un enrobage double couche spécial.
Designated States: AE, AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CR, CU, CZ, DM, DZ, EE, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, RO, RU, SD, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)