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1. (WO2000060100) DSP-9 DUAL-SPECIFICITY MAP KINASE PHOSPHATASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/060100    International Application No.:    PCT/US2000/009321
Publication Date: 12.10.2000 International Filing Date: 07.04.2000
Chapter 2 Demand Filed:    03.11.2000    
IPC:
C12N 9/16 (2006.01)
Applicants: CEPTYR, INC. [US/US]; 22215 - 26th Avenue Southeast, Bothell, WA 98021 (US) (For All Designated States Except US).
LUCHE, Ralf, M. [DE/US]; (US) (For US Only).
WEI, Bo [CN/US]; (US) (For US Only)
Inventors: LUCHE, Ralf, M.; (US).
WEI, Bo; (US)
Agent: ROSENMAN, Stephen, J.; Seed Intellectual Property Law Group PLLC, Suite 6300, 701 Fifth Avenue, Seattle, WA 98104-7092 (US).
GOWSHALL, Jon, V.; Forrester & Boehmert, Franz-Joseph-Strasse 38, D-80801 Munchen (DE)
Priority Data:
60/128,203 07.04.1999 US
Title (EN) DSP-9 DUAL-SPECIFICITY MAP KINASE PHOSPHATASE
(FR) PHOSPHATASE KINASE PROTEIQUE ACTIVEE PAR MITOGENE A DOUBLE SPECIFICITE DSP-9
Abstract: front page image
(EN)Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-9, and polypeptide variants thereof that stimulate dephosphorylation of DSP-9 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-9 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
(FR)L'invention concerne des compositions et des méthodes pour le traitement de maladies associées à la prolifération cellulaire, la différenciation cellulaire et/ou la survie cellulaire. L'invention concerne notamment la phosphatase à double spécificité DSP-9 ainsi que ses variantes polypeptidiques qui stimulent la déphosphorylation des substrats de DSP-9. Les polypeptides peuvent servir, par exemple, à identifier des anticorps et d'autres agents qui inhibent l'activité de DSP-9. Ces polypeptides et ces agents peuvent servir à moduler la prolifération cellulaire, la différenciation cellulaire et la survie cellulaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)