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Machine translation
1. (WO2000060054) PHARMACEUTICAL COMPOSITIONS COMPRISING CIRCULATING BLOOD CELLS, PREFERABLY MONOCYTES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/060054    International Application No.:    PCT/EP2000/003087
Publication Date: 12.10.2000 International Filing Date: 06.04.2000
Chapter 2 Demand Filed:    12.10.2000    
IPC:
A61K 47/48 (2006.01), C12N 5/0786 (2010.01), A61K 35/12 (2006.01), A61K 48/00 (2006.01)
Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE/DE]; Berlin (DE) (For All Designated States Except US).
BUSCHMANN, Ivo [DE/DE]; (DE) (For US Only).
SCHAPER, Wolfgang [DE/DE]; (DE) (For US Only)
Inventors: BUSCHMANN, Ivo; (DE).
SCHAPER, Wolfgang; (DE)
Agent: VOSSIUS & PARTNER; Siebertstrasse 4, D-81675 München (DE)
Priority Data:
99106800.8 06.04.1999 EP
Title (EN) PHARMACEUTICAL COMPOSITIONS COMPRISING CIRCULATING BLOOD CELLS, PREFERABLY MONOCYTES AND USES THEREOF
(FR) COMPOSITIONS PHARMACEUTIQUES RENFERMANT DES CELLULES DE SANG CIRCULANT, DE PREFERENCE DES MONOCYTES ET LEUR UTILISATION
Abstract: front page image
(EN)The present invention relates to a (pharmaceutical) composition comprising a circulating blood cell, preferably a monocyte loaded with a therapeutically active molecule and, optionally, a pharmaceutically acceptable carrier and/or diluent. Furthermore, the present invention relates to the use of a circulating blood cell, preferably a monocyte loaded with a therapeutically active molecule for the preparation of a (pharmaceutical) composition for enhancing collateral growth of collateral arteries and/or arteries from pre-existing arteriolar connections and/or preventing and/or treating an occlusive disease. The present invention also relates to a method for enhancing collateral growth of collateral arteries and/or arteries from pre-existing arteriolar connections, and/or preventing and/or treating an occlusive disease, said method comprising administering to a subject in need thereof an effective amount of circulating blood cells, preferably monocytes loaded with a therapeutically active molecule. Also described are (pharmaceutical) kits, diagnostic compositions, their preparation and use as well as diagnostic methods.
(FR)L'invention concerne une composition (pharmaceutique) renfermant une cellule de sang circulant, de préférence un monocyte chargé d'une molécule thérapeutiquement active et, facultativement, un vecteur pharmaceutiquement acceptable et/ou un diluant. En outre, l'utilisation d'une telle cellule, de préférence un monocyte chargé d'une molécule thérapeutiquement active, permet de préparer une composition (pharmaceutique) destinée à renforcer la croissance collatérale d'artères collatérales et/ou d'artères à partir de branchements artériolaires préexistants et/ou à prévenir et/ou à traiter des occlusions. De plus, un procédé permet de renforcer la croissance collatérale d'artères collatérales et/ou d'artères à partir de branchements artériolaires préexistants et/ou à prévenir et/ou à traiter des occlusions, ledit procédé consistant à administrer au patient concerné une dose efficace de cellules de sang circulant, de préférence des monocytes chargés d'une molécule thérapeutiquement active. L'invention traite enfin de trousses (pharmaceutiques), de compositions diagnostiques, de leur préparation et utilisation, ainsi de méthodes diagnostiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)