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1. (WO2000059912) THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF AND PROCESS FOR THE PREPARATION OF THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/059912    International Application No.:    PCT/JP2000/001957
Publication Date: 12.10.2000 International Filing Date: 29.03.2000
Chapter 2 Demand Filed:    07.09.2000    
IPC:
C07D 495/04 (2006.01)
Applicants: NIPPON SODA CO., LTD. [JP/JP]; 2-1, Ohtemachi 2-chome, Chiyoda-ku, Tokyo 100-8165 (JP) (For All Designated States Except US).
YAMADA, Hirokazu [JP/JP]; (JP) (For US Only).
UMEDA, Nobuhiro [JP/JP]; (JP) (For US Only).
UCHIDA, Seiichi [JP/JP]; (JP) (For US Only).
SHIINOKI, Yasuyuki [JP/JP]; (JP) (For US Only).
HORIKOSHI, Hiromi [JP/JP]; (JP) (For US Only).
MOCHIZUKI, Nobuo [JP/JP]; (JP) (For US Only)
Inventors: YAMADA, Hirokazu; (JP).
UMEDA, Nobuhiro; (JP).
UCHIDA, Seiichi; (JP).
SHIINOKI, Yasuyuki; (JP).
HORIKOSHI, Hiromi; (JP).
MOCHIZUKI, Nobuo; (JP)
Agent: TOKAI, Yusaku; Nippon Soda Co., Ltd., 2-1, Ohtemachi 2-chome, Chiyoda-ku, Tokyo 100-8165 (JP)
Priority Data:
11/87547 30.03.1999 JP
11/102287 09.04.1999 JP
Title (EN) THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF AND PROCESS FOR THE PREPARATION OF THE SAME
(FR) COMPOSES DE THIENOPYRIMIDINE ET LEURS SELS, ET PROCEDE DE PREPARATION DESDITS COMPOSES ET SELS
Abstract: front page image
(EN)Thieno[2,3-d]pyrimidine compounds of general formula (1) useful as drugs having a cGMP-specific phosphodiesterase inhibiting effect and so on; and a process for the preparation of the same wherein Q is a group represented by the general formula: (CH¿2?)¿n?-N(r¿1?)-C(r¿2?)(r¿3?), CH=CH-CH=CH, or (CH¿2?)¿m? which is bonded to a and b; R¿1? is hydrogen or C¿1?-C¿6? alkyl; R¿2? is C¿3?-C¿8? cycloalkyl optionally substituted with G¿1?, phenyl optionally substituted with G¿2?, or a saturated or unsaturated heterocyclic group having 1 to 4 heteroatoms selected from among N, O and S and being optionally substituted with G¿3?; and R¿3? is a saturated or unsaturated heterocyclic group having 1 to 4 heteroatoms selected from among N, O and S and being optionally substituted with G¿3? or a group represented by the general formula: (CH¿2?)¿k?C(=O)R¿4? or CH=CHC(O)R¿4?.
(FR)L'invention concerne des composés de thiéno[2,3-d]pyrimidine de la formule générale (1), qui sont utiles en tant que médicaments ayant un effet d'inhibition de la phosphodiestérase spécifique au cGMP, etc., et un procédé de préparation desdits composés. Dans ladite formule, Q est un groupe de la formule générale (CH¿2?)¿n?-N(r¿1?)-C(r¿2?)(r¿3?), CH=CH-CH=CH, ou (CH¿2?)¿m? lequel est lié à a et b; R¿1? est hydrogène ou alkyle C¿1?-C¿6?; R¿2? est cycloalkyle C¿3?-C¿8? éventuellement substitué par G¿1?, phényle éventuellement substitué par G¿2?, ou un groupe hétérocyclique saturé ou insaturé comprenant 1 à 4 hétéroatomes choisis entre N, O et S et éventuellement substitué par G¿3? ou un groupe de la formule générale (CH¿2?)¿k?C(=O)R¿4? ou CH=CHC(O)R¿4?.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)