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1. (WO2000059516) COMPOSITIONS OF POLYACIDS AND POLYETHERS AND METHODS FOR THEIR USE IN REDUCING ADHESIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2000/059516 International Application No.: PCT/US2000/007963
Publication Date: 12.10.2000 International Filing Date: 23.03.2000
Chapter 2 Demand Filed: 30.10.2000
IPC:
A61K 9/16 (2006.01) ,A61K 9/70 (2006.01) ,A61K 47/10 (2006.01) ,A61K 47/36 (2006.01) ,A61L 29/08 (2006.01) ,A61L 31/04 (2006.01) ,A61L 33/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
29
Materials for catheters or for coating catheters
08
Materials for coatings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
04
Macromolecular materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33
Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
06
Use of macromolecular materials
Applicants:
FZIOMED, INC. [US/US]; 170A Granada Drive San Luis Obispo, CA 93401, US
Inventors:
SCHWARTZ, Herbert, E.; US
BLACKMORE, John, M.; US
CORTESE, Stephanie, M.; US
OPPELT, William, G.; US
Agent:
MEYER, Sheldon, R. ; Fliesler, Dubb, Meyer and Lovejoy LLP Four Embarcadero Center Suite 400 San Francisco, CA 94111-4156, US
Priority Data:
09/472,11027.12.1999US
60/127,57102.04.1999US
Title (EN) COMPOSITIONS OF POLYACIDS AND POLYETHERS AND METHODS FOR THEIR USE IN REDUCING ADHESIONS
(FR) COMPOSITIONS DE POLYACIDES ET POLYETHERS ET PROCEDES D'UTILISATION DESTINES A LA REDUCTION D'ADHESIONS
Abstract:
(EN) The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other, and are then either dried into membranes or sponges, or are used as fluids or microspheres. Bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown $i(in-vivo), and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes and gels can be varied as needed by carefully adjusting the pH and/or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by conditioning the membranes prior to surgical use. Multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Membranes and gels can be used concurrently. Antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.
(FR) L'invention concerne des procédés améliorés de fabrication et d'utilisation de compositions bioadhésives, biorésorbables, anti-adhésives élaborées à partir de complexes intermacromoléculaires de polysaccharides contenant du carboxyle, de polyéthers, de polyacides, d'oxydes polyalcène, de cations multivalents et/ou de polycations. Les polymères sont associés les uns aux autres, et sont alors soit séchés en membranes ou éponges, soit utilisés en tant que fluides ou microsphères. Des compositions bioadhésives, biorésorbables, anti-adhésives sont utiles en chirurgie pour prévenir la formation ou la reformation d'adhésions post-chirurgicales. Les compositions sont conçues pour se briser $i(in-vivo), et on peut ainsi les enlever du corps. On introduit des membranes pendant l'opération, sèches ou facultativement obtenues après conditionnement dans des solutions aqueuses. On peut varier les propriétés anti-adhésives, bioadhésives, biorésorptrices, antithrombogéniques et physiques de tels membranes et gels, suivant les besoins, en adaptant, avec précaution, le pH et/ou le contenu de cations des solutions de coulée de polymère, de la composition de polyacide, de la composition d'oxyde de polyalcène, ou en conditionnant les membranes avant utilisation chirurgicale. On peut élaborer et utiliser des membranes à couches multiples pour obtenir une régulation complémentaire des propriétés physiques et biologiques des membranes anti-adhésives. On utilise parallèlement des membranes et des gels. On peut utiliser des compositions anti-adhésives pour lubrifier des tissus et/ou des instruments médicaux, et/ou administrer des médicaments à un emplacement chirurgicale et les libérer localement.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)