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1. (WO2000059502) PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/059502    International Application No.:    PCT/US2000/008996
Publication Date: 12.10.2000 International Filing Date: 05.04.2000
Chapter 2 Demand Filed:    03.11.2000    
IPC:
C07D 401/06 (2006.01), C07D 401/14 (2006.01), C07D 409/14 (2006.01), C07D 413/14 (2006.01), C07D 417/14 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 513/04 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
CHAPMAN, Kevin [US/US]; (US) (For US Only).
HALE, Jeffrey [US/US]; (US) (For US Only).
KIM, Dooseop [KR/US]; (US) (For US Only).
LYNCH, Christopher [US/US]; (US) (For US Only).
SHAH, Shrenik [US/US]; (US) (For US Only).
SHANKARAN, Kothandaraman [US/US]; (US) (For US Only).
SHEN, Dong-Ming [US/US]; (US) (For US Only).
WILLOUGHBY, Christopher [US/US]; (US) (For US Only).
MACCOSS, Malcolm [GB/US]; (US) (For US Only).
MILLS, Sander, G. [US/US]; (US) (For US Only).
LOEBACH, Jennifer, L. [US/US]; (US) (For US Only).
GUTHIKONDA, Ravindra, N. [US/US]; (US) (For US Only)
Inventors: CHAPMAN, Kevin; (US).
HALE, Jeffrey; (US).
KIM, Dooseop; (US).
LYNCH, Christopher; (US).
SHAH, Shrenik; (US).
SHANKARAN, Kothandaraman; (US).
SHEN, Dong-Ming; (US).
WILLOUGHBY, Christopher; (US).
MACCOSS, Malcolm; (US).
MILLS, Sander, G.; (US).
LOEBACH, Jennifer, L.; (US).
GUTHIKONDA, Ravindra, N.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/128,033 06.04.1999 US
Title (EN) PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
(FR) PYRROLIDINES MODULATEURS DE L'ACTIVITE DU RECEPTEUR DE CHIMIOKINE
Abstract: front page image
(EN)The present invention is directed to pyrrolidine compounds of formula (I) (wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?14¿ and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
(FR)La présente invention concerne des composés de pyrrolidine de formule (I) (dans laquelle: R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?14¿ et n sont tels que définis dans la description) utiles en tant que modulateurs de l'activité du récepteur de la chimiokine. En particulier ces composés sont utiles en tant que modulateurs des récepteurs CCR-5 et/ou CCR-3 de la chimiokine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)