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1. (WO2000058499) PROCESS FOR PRODUCING MONOCLONAL ANTIBODY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/058499    International Application No.:    PCT/JP2000/002022
Publication Date: 05.10.2000 International Filing Date: 30.03.2000
Chapter 2 Demand Filed:    08.09.2000    
IPC:
C07K 16/00 (2006.01), C12N 15/85 (2006.01)
Applicants: JAPAN TOBACCO INC. [JP/JP]; 2-1, Toranomon 2-chome, Minato-ku, Tokyo 105-8422 (JP) (For All Designated States Except US).
ABGENIX, INC. [US/US]; 7601 Dumbarton Circle, Fremont, CA 94555 (US) (For All Designated States Except US).
KUSUNOKI, Chihiro [JP/JP]; (JP) (For US Only).
FUKUSHIMA, Atsushi [JP/JP]; (JP) (For US Only)
Inventors: KUSUNOKI, Chihiro; (JP).
FUKUSHIMA, Atsushi; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Building 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 300-0847 (JP)
Priority Data:
11/87929 30.03.1999 JP
Title (EN) PROCESS FOR PRODUCING MONOCLONAL ANTIBODY
(FR) PROCEDE POUR LA PRODUCTION D'ANTICORPS MONOCLONAL
Abstract: front page image
(EN)Recombinant hybridomas are constructed by transferring a gene encoding an amino acid sequence, which is identical with the amino acid sequence of the heavy chain polypeptide of a specific monoclonal antibody, into immortalized B cells (hybridomas) producing this monoclonal antibody, thereby obtaining the monoclonal antibody in a significantly elevated amount from the liquid culture medium of the cells.
(FR)Selon l'invention, des hybridomes de recombinaison sont produits par transfert d'un gène, qui code une séquence d'acides aminés identique à celle du polypeptide à chaîne lourde d'un anticorps monoclonal spécifique, dans des lymphocytes B immortalisés (hybridomes) produisant cet anticorps monoclonal, ce qui permet d'obtenir ledit anticorps monoclonal dans des quantités très importantes, à partir du milieu de culture liquide desdits lymphocytes B.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)