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Machine translation
1. (WO2000058296) PROTEASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/058296    International Application No.:    PCT/US2000/008833
Publication Date: 05.10.2000 International Filing Date: 31.03.2000
Chapter 2 Demand Filed:    12.09.2000    
IPC:
C07D 321/12 (2006.01), C07D 405/12 (2006.01), C07D 409/12 (2006.01)
Applicants: SMITHKLINE BEECHAM CORPORATION [US/US]; One Franklin Plaza, Philadelphia, PA 19103 (US) (For All Designated States Except US).
YAMASHITA, Dennis, S. [US/US]; (US) (For US Only)
Inventors: YAMASHITA, Dennis, S.; (US)
Agent: STERCHO, Yuriy, P.; SmithKline Beecham Corporation, Corporate Intellectual Property, UW2220, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939 (US)
Priority Data:
60/127,250 31.03.1999 US
Title (EN) PROTEASE INHIBITORS
(FR) INHIBITEURS DE PROTEASE
Abstract: front page image
(EN)The present invention provides 4-amino-4,5-dihydro-benzo[b][1,4] dioxocin-3-one protease inhibitors, and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
(FR)La présente invention concerne des inhibiteurs de protéase 4-amino-4,5-dihydro-benzo[b][1,4] dioxocin-3-one, et des sels pharmaceutiquement acceptables, leurs hydrates et leurs solvates inhibiteurs de protéase, comprenant de la cathépsine K, les compositions pharmaceutiques de ces composés. L'invention concerne également des procédés de traitement des maladies de perte osseuse excessive ou de dégénérescence de cartilage ou de la matrice, y compris l'ostéoporose; la maladie gingivale y compris la gingivite et la paradontite; l'arthrite, plus particulièrement, ostéoarthrite et la polyarthrite rhumatoïde; la maladie de Paget; l'hypercalcémie paranéoplasique; et la maladie métabolique des os, comportant l'inhibition de ladite perte osseuse excessive ou la dégénérescence excessive du cartilage ou de la matrice par l'administration à un patient qui en a besoin un composé de la présente invention.
Designated States: AE, AG, AL, AU, BA, BB, BG, BR, CA, CN, CZ, DZ, EE, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KP, KR, LC, LK, LR, LT, LV, MA, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, TZ, UA, US, UZ, VN, YU, ZA.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)