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Machine translation
1. (WO2000058270) HSV PRIMASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/058270    International Application No.:    PCT/CA2000/000324
Publication Date: 05.10.2000 International Filing Date: 23.03.2000
Chapter 2 Demand Filed:    16.10.2000    
IPC:
A61K 31/165 (2006.01), A61K 31/167 (2006.01), A61K 31/4402 (2006.01), A61K 31/4453 (2006.01), A61K 31/522 (2006.01), A61P 31/22 (2006.01), C07C 235/00 (2006.01), C07C 235/60 (2006.01), C07C 235/62 (2006.01), C07C 235/64 (2006.01), C07C 237/42 (2006.01), C07D 213/30 (2006.01), C07D 213/40 (2006.01), C07D 295/18 (2006.01)
Applicants: BOEHRINGER INGELHEIM (CANADA) LTD. [CA/CA]; 2100 Cunard Street, Laval, Quebec H7S 2G5 (CA) (For All Designated States Except US).
SIMONEAU, Bruno [CA/CA]; (CA) (For US Only).
LIUZZI, Michele [CA/CA]; (CA) (For US Only).
MENTRUP, Anton [DE/DE]; (DE) (For US Only)
Inventors: SIMONEAU, Bruno; (CA).
LIUZZI, Michele; (CA).
MENTRUP, Anton; (DE)
Agent: BERNIER, Louise, G.; Boehringer Ingelheim (Canada) Ltd., 2100 Cunard, Laval, Quebec H7S 2G5 (CA)
Priority Data:
60/125,165 25.03.1999 US
Title (EN) HSV PRIMASE INHIBITORS
(FR) INHIBITEURS DE LA PRIMASE DU VIRUS HERPES SIMPLEX
Abstract: front page image
(EN)The invention provides compounds of formula (1) that are active against the HSV primase enzyme: wherein R¿1? is hydroxy or amino; R¿2? is hydrogen, halo, (C¿1-4?)alkyl or (C¿1-4?)alkoxy; R¿3? is hydrogen, halo, (C¿1-4?)alkyl, (C¿1-4?)alkoxy, amino or azido; R¿4? has the same significance as R¿2?; R¿5? is hydrogen or (C¿1-4?)alkyl; and R is (C¿1-7?)alkyl, (C¿3-6?)cycloalkyl, {phenyl(C¿1-7?)alkyl}, {phenyl(C¿1-7?)alkoxy}, {{(monocyclic heterocyclo)-{(C¿1-7?)alkoxy}}, CH(W)C(O){O-(C¿1-4?)alkyl} wherein W is hydrogen or (C¿1-7?)alkyl, or (a) wherein Y is hydrogen or (C¿1-7?)alkyl, and Z is (C¿1-7?)alkyl, (C¿3-6?) cycloalkyl, {(C¿3-6?)cycloalkyl}-{(C¿1-7?)alkyl}, phenyl(C¿1-7?)alkyl or {{(monocyclic heterocyclo)-{(C¿1-7?)alkyl}}, or Y and Z together with the nitrogen atom to which they are attached represent, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl or 1-(4-methylpiperazinyl); with the provisos that (1) when R is CH(W)C(O)-{O-(C¿1-4?)alkyl} as defined herein, then R¿5? is hydrogen; and (2) at least one of R¿2?, R¿3? and R¿4? is other than hydrogen.
(FR)L'invention concerne des composés de la formule 1 qui agissent à l'encontre de l'enzyme de la primase du virus herpès simplex, formule dans laquelle R¿1? désigne hydroxy ou amino; R¿2? désigne hydrogène, halo, alkyle(C¿1-4?) ou alcoxy(C¿1-4?); R¿3? désigne hydrogène, halo, alkyle(C¿1-4?), alcoxy(C¿1-4?), amino ou azido; R¿4? a la même signification que R¿2 ?; R¿5? désigne hydrogène ou alkyle(C¿1-4?); et R désigne alkyle(C¿1-7?), cycloalkyle(C¿3-6?), {phényle(C¿1-7?)alkyle}, {phényle(C¿1-7?)alcoxy}, {{(hétéocyclo monocyclique)-alcoxy(C¿1-7?)}}; CH(W)C(O){O-alkyle(C¿1-4?)} où W désigne hydrogène ou alkyle(C¿1-7?) ou (a) où Y désigne hydrogène ou alkyle(C¿1-7?), et Z désigne alkyle(C¿1-7?), cycloalkyle(C¿3-6?), {cycloalkyle(C¿3-6?)}-{alkyle(C¿1-7?)}, phényle(C¿1-7?)alkyle ou {{hétérocyclo monocyclique)-{alkyle(C¿1-7?)}}, ou Y et Z désignent conjointement avec l'atome d'azote auquel ils sont liés, 1-pyrrolidinyle, 1-pipéridinyle, 4-morpholinyle ou 1-(4-méthylpipérazinyle); sous réserve que (1) si R désigne CH(W)C(O)-{O-(alkyle(C¿1-4?)} comme défini précédemment, R?5¿ désigne alors hydrogène; et (2) qu'au moins un des restes R¿2?,R¿3? et R¿4? soit différent d'hydrogène.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)