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1. (WO2000058256) PROCESS FOR THE PREPARATION OF 3,4-DIHYDROXYBUTANOIC ACID AND DERIVATIVES THEREOF FROM SUBSTITUTED PENTOSE SUGARS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/058256    International Application No.:    PCT/US2000/004155
Publication Date: 05.10.2000 International Filing Date: 17.02.2000
Chapter 2 Demand Filed:    11.10.2000    
IPC:
C07C 51/285 (2006.01), C07D 307/33 (2006.01)
Applicants: MICHIGAN STATE UNIVERSITY [US/US]; 238 Administration Building, East Lansing, MI 48824 (US)
Inventors: HOLLINGSWORTH, Rawle, I.; (US)
Agent: MCLEOD, Ian, C.; 2190 Commons Parkway, Okemos, MI 48864 (US)
Priority Data:
09/282,779 31.03.1999 US
Title (EN) PROCESS FOR THE PREPARATION OF 3,4-DIHYDROXYBUTANOIC ACID AND DERIVATIVES THEREOF FROM SUBSTITUTED PENTOSE SUGARS
(FR) PROCEDE DE PREPARATION D'ACIDE 3,4-DIHYDROXYBUTANOIQUE ET DERIVES CORRESPONDANTS DE SUCRES PENTOSES SUBSTITUTES
Abstract: front page image
(EN)A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-$g(g)-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic acid and (R)-3-hydroxy-$g(g)-butyrolactone from a 3-leaving group substituted L-pentose sugars. The process uses a base and a peroxide to convert the pentose source to the chiral 3,4-dihydroxybutanoic acid compound. The chiral 3,4-dihydroxybutanoic acid can be further converted to 3-hydroxy-$g(g)-butyrolactone by acidification. The chiral compound is useful as a chemical intermediate to the synthesis of various drugs and other products.
(FR)L'invention concerne un procédé de préparation d'acide 3,4-dihydroxybutanoïque (I) et de 3-hydroxy-$g(g)-butyrolactone (V) correspondant à partir d'une source de pentose substituée par un groupe 3 labile. Notamment, le procédé concerne la synthèse de l'acide (R)-3,4-dihydroxybutanoïque et de (R)-3-hydroxy-$g(g)-butyrolactone à partir d'une source de L-pentose substituée par un groupe 3 labile. Le procédé met en oeuvre une base et un peroxyde pour convertir la source de pentose en un composé d'acide 3,4-dihydroxybutanoïque chiral. L'acide 3,4-dihydroxybutanoïque chiral peut être encore converti en 3-hydroxy-$g(g)-butyrolactone par acidification. Le composé chiral est utile en tant qu'intermédiaire chimique à la synthèse de divers médicaments et d'autres produits.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)