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Machine translation
1. (WO2000057890) PULMONARY DELIVERY OF PROTONATED/ACIDIFIED NUCLEIC ACIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/057890    International Application No.:    PCT/US2000/008244
Publication Date: 05.10.2000 International Filing Date: 28.03.2000
Chapter 2 Demand Filed:    12.09.2000    
IPC:
A61K 9/12 (2006.01), A61K 9/127 (2006.01), A61K 31/7088 (2006.01), A61P 11/00 (2006.01), A61P 31/04 (2006.01)
Applicants: OLIGOS ETC. INC. [US/US]; Building C6, 9775 SW Commerce Circle, Wilsonville, OR 97070 (US) (For All Designated States Except US).
DALE, Roderic, M., K. [US/US]; (US) (For US Only).
GATTON, Steven, L. [US/US]; (US) (For US Only).
ARROW, Amy [US/US]; (US) (For US Only)
Inventors: DALE, Roderic, M., K.; (US).
GATTON, Steven, L.; (US).
ARROW, Amy; (US)
Agent: DEVORE, Dianna, L.; Bozicevic, Field & Francis LLP, Suite 200, 200 Middlefield Road, Menlo Park, CA 94025 (US)
Priority Data:
09/282,824 31.03.1999 US
Title (EN) PULMONARY DELIVERY OF PROTONATED/ACIDIFIED NUCLEIC ACIDS
(FR) ADMINISTRATION PAR VOIE PULMONAIRE D'ACIDES NUCLEIQUES PROTONES/ACIDIFIES
Abstract: front page image
(EN)The present invention provides a method of treating bacterial respiratory infections by pulmonary administration of protonated/acidified nucleic acids. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule.
(FR)L'invention concerne une méthode de traitement d'infections respiratoires bactériennes par administration par voie pulmonaire d'acides nucléiques protonés/acidifiés. Ces acides nucléiques modifiés sont efficaces en tant qu'agents bactéricides et/ou bactériostatiques indépendamment de la classe des bactéries, et sont particulièrement utiles en cas de diagnostics difficiles ou en présence de multiples organismes infectieux. L'activité antibiotique des acides nucléiques de l'invention ne dépend pas de la séquence spécifique de l'acide nucléique ni de la longueur de la molécule d'acide nucléique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)