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Machine translation
1. (WO2000057881) CILOSTAZOL PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/057881    International Application No.:    PCT/JP2000/001722
Publication Date: 05.10.2000 International Filing Date: 21.03.2000
Chapter 2 Demand Filed:    18.10.2000    
IPC:
A61K 9/14 (2006.01), A61K 9/16 (2006.01), A61K 9/20 (2006.01), A61K 9/50 (2006.01), A61K 31/4709 (2006.01)
Applicants: OTSUKA PHARMACEUTICAL CO., LTD. [JP/JP]; 9, Kandatsukasa-cho 2-chome, Chiyoda-ku, Tokyo 101-8535 (JP) (For All Designated States Except US).
MUKAI, Tadashi [JP/JP]; (JP) (For US Only).
TOMOHIRA, Yuso [JP/JP]; (JP) (For US Only).
TODA, Masafumi [JP/JP]; (JP) (For US Only).
YAMADA, Keigo [JP/JP]; (JP) (For US Only).
OKA, Yoshikazu [JP/JP]; (JP) (For US Only)
Inventors: MUKAI, Tadashi; (JP).
TOMOHIRA, Yuso; (JP).
TODA, Masafumi; (JP).
YAMADA, Keigo; (JP).
OKA, Yoshikazu; (JP)
Agent: KAMEI, Hirokatsu; AI Association of Patent and Trademark Attorneys, Jyutakukinyukoko-Sumitomoseimei Building 12F, 5-20, Minamihommachi 4-chome, Chuo-ku, Osaka-shi, Osaka 541-0054 (JP)
Priority Data:
11/81363 25.03.1999 JP
11/279147 30.09.1999 JP
Title (EN) CILOSTAZOL PREPARATION
(FR) PREPARATION AU CILOSTAZOL
Abstract: front page image
(EN)Provided is a cilostazol preparation which comprises incorporating a fine powder of cilostazol into a dispersing and/or solubilizing agent thereby to enhance the dispersibility and/or solubility. Further, provided is a process for improving absorbability of a slightly soluble drug such as cilostazol even at the lower portion of the digestive tract, wherein said drug is hard to be absorbed at the lower portion of the digestive tract when a conventional method is used. According to the present invention, cilostazol is absorbed enough even at the lower portion of the digestive tract to have an effect as thrombolytic drug, cerebral circulation improving drug or the like.
(FR)La présente invention concerne une préparation au cilostazol pour laquelle on incorpore une fine poudre de cilostazol dans un agent dispersant et/ou solubilisant de façon à en augmenter la dispersabilité et/ou la solubilité. L'invention concerne également un procédé permettant d'augmenter l'absorbabilité d'un médicament faiblement soluble tel que le cilostazol, même dans la partie inférieure des voies digestives. En effet, ce médicament est difficile à absorber dans la partie inférieure des voies digestives lorsqu'on utilise le procédé conventionnel. Selon l'invention, le cilostazol s'absorbe en quantité suffisante, même dans la partie inférieure des voies digestives, pour avoir une action en tant que thrombolytique, et que médicament améliorant la circulation cérébrale, ou analogue.
Designated States: AU, BR, CA, CN, ID, IN, KR, MX, SG, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)