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1. (WO2000057877) ARYL SUBSTITUTED PYRAZOLES, IMIDAZOLES, OXAZOLES, THIAZOLES AND PYRROLES, AND THE USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/057877    International Application No.:    PCT/US2000/007944
Publication Date: 05.10.2000 International Filing Date: 24.03.2000
Chapter 2 Demand Filed:    22.09.2000    
IPC:
C07D 207/416 (2006.01), C07D 231/12 (2006.01), C07D 233/54 (2006.01), C07D 235/18 (2006.01), C07D 263/34 (2006.01), C07D 277/56 (2006.01), C07D 403/04 (2006.01)
Applicants: EURO-CELTIQUE S.A.; 122, Boulevard de la Petrusse, L-2330 Luxembourg (LU) (For All Designated States Except US).
HOGENKAMP, Derk, J. [US/US]; (US) (For US Only).
UPASANI, Ravindra [IN/US]; (US) (For US Only).
NGUYEN, Phong [US/US]; (US) (For US Only)
Inventors: HOGENKAMP, Derk, J.; (US).
UPASANI, Ravindra; (US).
NGUYEN, Phong; (US)
Agent: COVERT, John, M.; Sterne, Kessler, Goldstein & Fox P.L.L.C., Suite 600, 1100 New York Avenue, N.W., Washington, DC 20005-3934 (US)
Priority Data:
60/126,553 26.03.1999 US
Title (EN) ARYL SUBSTITUTED PYRAZOLES, IMIDAZOLES, OXAZOLES, THIAZOLES AND PYRROLES, AND THE USE THEREOF
(FR) PYRAZOLES, IMIDAZOLES, OXAZOLES, THIAZOLES ET PYRROLES ARYLE SUBSTITUES ET LEURS UTILISATIONS
Abstract: front page image
(EN)This invention relates to compounds having Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R¿5?-R¿13? are set in the specification. The invention also is directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
(FR)L'invention concerne de composés correspondant à la formule (I) ou leurs sels, promédicaments ou solvates pharmaceutiquement acceptables, dans laquelle Het et R¿5?-R¿13? sont spécifiés dans la description. L'invention concerne également l'utilisation de composés de formule (I) pour traiter les lésions neuronales consécutives à une ischémie globale ou focale, pour traiter ou prévenir des états neurodégénératifs tels que la sclérose latérale amyotrophique (ALS), pour traiter, prévenir ou améliorer une douleur chronique ou aiguë et pour traiter ou prévenir la neuropathie diabétique. Ces composés sont notamment des agents anti-acouphènes, des anticonvulsivants, des anti-maniaco-dépresseurs, des anesthésiques locaux et des antiarythmiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)