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Machine translation
1. (WO2000057701) PROSTAGLANDIN COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING PERIPHERAL VASCULAR DISEASE AND PULMONARY HYPERTENSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/057701    International Application No.:    PCT/US2000/008240
Publication Date: 05.10.2000 International Filing Date: 29.03.2000
Chapter 2 Demand Filed:    26.09.2000    
IPC:
C07C 405/00 (2006.01), C07D 307/937 (2006.01)
Applicants: UNITED THERAPEUTICS CORPORATION [US/US]; 110 Spring Street, Silver Spring, MD 20910 (US) (For All Designated States Except US).
SHORR, Robert [US/US]; (US) (For US Only).
ROTHBLATT, Martine [US/US]; (US) (For US Only).
BENTLEY, Michael, D. [US/US]; (US) (For US Only).
ZHAO, Xuan [US/US]; (US) (For US Only)
Inventors: SHORR, Robert; (US).
ROTHBLATT, Martine; (US).
BENTLEY, Michael, D.; (US).
ZHAO, Xuan; (US)
Agent: KIPNES, Allen, R.; Watov & Kipnes, P.C., P.O. Box 247, Princeton Junction, NJ 08550 (US)
Priority Data:
60/127,254 31.03.1999 US
60/127,255 31.03.1999 US
Title (EN) PROSTAGLANDIN COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING PERIPHERAL VASCULAR DISEASE AND PULMONARY HYPERTENSION
(FR) COMPOSES DE PROSTAGLANDINE, COMPOSITIONS ET METHODES DE TRAITEMENT DE MALADIES VASCULAIRES PERIPHERIQUES ET DE L'HYPERTENSION PULMONAIRE
Abstract: front page image
(EN)Prostaglandin and analogs thereof which include protective groups attached to at least one site which are pharmaceutically acceptable and which are capable of slowing the metabolic rate of the active groups for administration to a warm blooded animal for the treatment of peripheral vascular disease and pulmonary hypertension. In fact, Figure 1 graphically shows the effects on pulmonary arterial pressure of a dose of mPEG20kDa-aminde-Compound X, given as an intravenous infusion to a sheep intravenously-induced with a pulmonary hypertensive agent.
(FR)L'invention concerne la prostaglandine et des analogues de cette dernière contenant des groupes protecteurs fixés à au moins un site, et étant pharmaceutiquement acceptables et capables de ralentir le rythme métabolique des groupes actifs en vue d'une administration à des animaux à sang chaud pour le traitement de maladies vasculaires périphériques et de l'hypertension pulmonaire. La figure illustre les effets d'une dose de mPEG20kDa-amide-Composé X sur la pression artérielle pulmonaire, administré sous forme d'infusion intraveineuse à un mouton ayant reçu, par voie intraveineuse, un agent d'hypertension pulmonaire.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)