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1. (WO2000056376) MEDICAL DEVICES AND APPLICATIONS OF POLYHYDROXYALKANOATE POLYMERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2000/056376 International Application No.: PCT/US2000/007890
Publication Date: 28.09.2000 International Filing Date: 24.03.2000
Chapter 2 Demand Filed: 19.10.2000
IPC:
A61L 17/12 (2006.01) ,A61L 27/18 (2006.01) ,A61L 31/06 (2006.01) ,C08G 63/06 (2006.01) ,C08K 5/00 (2006.01) ,C12P 7/62 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
17
Materials for surgical sutures or for ligaturing blood vessels
06
At least partly resorbable materials
10
containing macromolecular materials
12
Homopolymers or copolymers of glycolic or lactic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
18
obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
04
Macromolecular materials
06
obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
63
Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
02
Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds
06
derived from hydroxy carboxylic acids
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
K
USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES AS COMPOUNDING INGREDIENTS
5
Use of organic ingredients
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
62
Carboxylic acid esters
Applicants:
METABOLIX, INC. [US/US]; 303 Third Street Cambridge, MA 02142-1196, US
Inventors:
WILLIAMS, Simon, F.; US
MARTIN, David, P.; US
SKRALY, Frank; US
Agent:
PABST, Patrea, L. ; Arnall Golden & Gregory, LLP 2800 One Atlantic Center 1201 West Peachtree Street Atlanta, GA 30309-3450, US
Priority Data:
60/126,18025.03.1999US
60/142,23802.07.1999US
Title (EN) MEDICAL DEVICES AND APPLICATIONS OF POLYHYDROXYALKANOATE POLYMERS
(FR) UTILISATIONS ET APPLICATIONS MEDICALES DE POLYMERES DE POLYHYDROXYALCANOATE
Abstract:
(EN) Devices formed of or including biocompatible polyhydroxylkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating system, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.
(FR) On décrit des dispositifs formés de polyhydroxyalcanoates biocompatibles ou contenant ces derniers qui ont des vitesses de décomposition contrôlées de préférence inférieures à une année dans des conditions physiologiques. Les dispositifs préférés comprennent les sutures, les fixations pour suture, les dispositifs de réparation du ménisque, les rivets, les collants, les agrafes, les vis (y compris les vis de serrage), les plaques pour les os et les systèmes de plaque vissée pour les os, le tissu maillé chirurgical, les pièces de réparation, les toiles ou selles, les pièces cardio-vasculaires, les broches orthopédiques (y compris la matière augmentant l'ostéo-remplissage ), les barrières adhérentes, les stents, les dispositifs guidés de réparation/régénération des tissus, les dispositifs de réparation du cartilage articulaire, les tubes guides nerveux, les dispositifs de réparation des tendons, les dispositifs de réparation de communication interauriculaire, les pièces péricardiques, les agents d'étoffement et de remplissage, les valves veineuses, les structures de soutien de la moelle épinière, les dispositifs de régénération du ménisque, les greffes de ligament et de tendon, les implants de cellules oculaires, les cages de fusion de vertèbres, les substituts de peau, les substituts de dure-mère, les substituts de greffe osseuse, les ancrages osseux, les pansements pour plaies et les dispositifs hémostatiques. Les polyhydroxyalcanoates peuvent contenir des additifs, peuvent être formés de mélanges de monomères ou peuvent comprendre des groupes pendants ou des modifications dans leurs squelettes, ou bien encore peuvent être chimiquement modifiés, et tout cela en vue de modifier les vitesses de décomposition. Les compositions de polyhydroxyalcanoate présentent également des propriétés favorables relatives à l'aspect mécanique et à la biocompatibilité et des vitesses de décomposition qui se situent dans des fourchettes de temps souhaitables dans des conditions physiologiques.
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Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1163019EP1867348EP2305324JP2002539854 CA2368470DK1163019
AU2000040277