Processing

Please wait...

Settings

Settings

1. WO2000043787 - ELECTROPHORETIC ASSAYS TO ASSESS CONFORMATIONAL CHANGES OF INTEGRINS INDUCED BY LIGAND BINDING

Publication Number WO/2000/043787
Publication Date 27.07.2000
International Application No. PCT/US2000/001774
International Filing Date 26.01.2000
Chapter 2 Demand Filed 27.07.2000
IPC
G01N 33/561 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
558using diffusion or migration of antigen or antibody
561Immunoelectrophoresis
G01N 33/566 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
566using specific carrier or receptor proteins as ligand binding reagent
CPC
C02F 1/4696
CCHEMISTRY; METALLURGY
02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
1Treatment of water, waste water, or sewage
46by electrochemical methods
469by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
4696electrophoresis
C07K 1/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
14Extraction; Separation; Purification
24by electrochemical means
26Electrophoresis
G01N 2500/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Applicants
  • DU PONT PHARMACEUTICALS COMPANY [US/US]; Chestnut Run Plaza 974 Centre Road Wilmington, DE 19807, US
Inventors
  • WYNN, Richard; US
  • ZOLOTARARJOVA, Nina, I.; US
Agents
  • RUBIN, Kenneth, B.; Du Pont Pharmaceuticals Company Legal Patent Records Center 1007 Market Street Wilmington, DE 19898, US
Priority Data
60/117,25726.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ELECTROPHORETIC ASSAYS TO ASSESS CONFORMATIONAL CHANGES OF INTEGRINS INDUCED BY LIGAND BINDING
(FR) TESTS D'ELECTROPHORESE PERMETTANT D'EVALUER LES CHANGEMENTS DE CONFORMATION DES INTEGRINES INDUITS PAR LEUR LIAISON AVEC UN LIGAND
Abstract
(EN)
This invention relates to electrophoretic assays useful for the detection of conformational changes in integrin structure upon binding of antagonists, agonists or ligands. Such assays are useful to identify drug candidate compounds that may have a high potential for side reactions when administered in patients.
(FR)
L'invention concerne des procédés d'électrophorèse permettant la détection de changements de conformation de la structure des intégrines après leur liaison avec des antagonistes, des agonistes ou des ligands. Ces procédés sont utiles pour l'identification de composés médicamenteux potentiels pouvant présenter un risque élevé d'effets secondaires lors de leur administration à des patients.
Also published as
Latest bibliographic data on file with the International Bureau